Biodegradable polymer scaffolds to regenerate organs

R. C. Thomson, M. C. Wake, M. J. Yaszemski, A. G. Mikos

Research output: Contribution to journalArticle

161 Scopus citations

Abstract

The problem of donor scarcity precludes the widespread utilization of whole organ transplantation as a therapy to treat many diseases for which there is often no alternative treatment. Cell transplantation using biodegradable polymer scaffolds offers the possibility to create completely natural new tissue and replace organ function. Tissue inducing biodegradable polymers can also be utilized to regenerate certain tissues and without the need for in vitro cell culture. Biocompatible, biodegradable polymers play an important role in organ regeneration as temporary substrates to transplanted cells which allow cell attachment, growth, and retention of differentiated function. Novel processing techniques have been developed to manufacture reproducibly scaffolds with high porosities for cell seeding and large surface areas for cell attachment. These scaffolds have been used to demonstrate the feasibility of regenerating several organs.

Original languageEnglish (US)
Pages (from-to)218-274
Number of pages57
JournalAdvances in Polymer Science
Volume122
DOIs
StatePublished - 1995

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Organic Chemistry
  • Polymers and Plastics

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