Biodegradable polymer grafts for surgical repair of the injured spinal cord

Jonathan A. Friedman, Anthony John Windebank, Michael J. Moore, Robert J. Spinner, Bradford L. Currier, Michael J Yaszemski, Juán Bartolomei, Joseph M. Piepmeier, Gordon Chu, Michael G. Fehlings, Charles J. Hodge, Franklin C. Wagner

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

PURPOSE: Biodegradable polymers have been used in the surgical repair of peripheral nerves, but their potential for use in the central nervous system has not been exploited adequately. This article discusses concepts related to the engineering of a biodegradable polymer graft for surgical repair of the injured spinal cord and explores the potential means by which such a device might promote axon regeneration and functional recovery after spinal cord injury. CONCEPT: A biodegradable polymer implant with controlled microarchitecture can be engineered, and its composition can be optimized for implantation in the spinal cord. RATIONALE: The use of a biodegradable polymer implant has the dual advantages of providing a structural scaffold for axon growth and a conduit for sustained-release delivery of therapeutic agents. As a scaffold, the microarchitecture of the implant can be engineered for optimal axon growth and transplantation of permissive cell types. As a conduit for the delivery of therapeutic agents that may promote axon regeneration, the biodegradable polymer offers an elegant solution to the problems of local delivery and controlled release over time. Thus, a biodegradable polymer graft would theoretically provide an optimal structural, cellular, and molecular framework for the regrowth of axons across a spinal cord lesion and, ultimately, neurological recovery. CONCLUSION: Biodegradable polymer grafts may have significant therapeutic potential in the surgical repair of the injured spinal cord. Further research should be focused on the bioengineering, characterization, and experimental application of these devices.

Original languageEnglish (US)
Pages (from-to)742-752
Number of pages11
JournalNeurosurgery
Volume51
Issue number3
DOIs
StatePublished - Sep 1 2002

Fingerprint

Spinal Cord Regeneration
Polymers
Transplants
Axons
Absorbable Implants
Regeneration
Spinal Cord
Bioengineering
Equipment and Supplies
Cell Transplantation
Growth
Spinal Cord Injuries
Peripheral Nerves
Therapeutics
Central Nervous System

Keywords

  • Axon regeneration
  • Biodegradable polymer
  • Neurotrophic factors
  • Schwann cell
  • Spinal cord injury

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Biodegradable polymer grafts for surgical repair of the injured spinal cord. / Friedman, Jonathan A.; Windebank, Anthony John; Moore, Michael J.; Spinner, Robert J.; Currier, Bradford L.; Yaszemski, Michael J; Bartolomei, Juán; Piepmeier, Joseph M.; Chu, Gordon; Fehlings, Michael G.; Hodge, Charles J.; Wagner, Franklin C.

In: Neurosurgery, Vol. 51, No. 3, 01.09.2002, p. 742-752.

Research output: Contribution to journalArticle

Friedman, JA, Windebank, AJ, Moore, MJ, Spinner, RJ, Currier, BL, Yaszemski, MJ, Bartolomei, J, Piepmeier, JM, Chu, G, Fehlings, MG, Hodge, CJ & Wagner, FC 2002, 'Biodegradable polymer grafts for surgical repair of the injured spinal cord', Neurosurgery, vol. 51, no. 3, pp. 742-752. https://doi.org/10.1097/00006123-200209000-00024
Friedman, Jonathan A. ; Windebank, Anthony John ; Moore, Michael J. ; Spinner, Robert J. ; Currier, Bradford L. ; Yaszemski, Michael J ; Bartolomei, Juán ; Piepmeier, Joseph M. ; Chu, Gordon ; Fehlings, Michael G. ; Hodge, Charles J. ; Wagner, Franklin C. / Biodegradable polymer grafts for surgical repair of the injured spinal cord. In: Neurosurgery. 2002 ; Vol. 51, No. 3. pp. 742-752.
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