TY - JOUR
T1 - Biochemistry of the filaments of brain
AU - Yen, S. H.
AU - Dahl, D.
AU - Schachner, M.
AU - Shelanski, M. L.
PY - 1976
Y1 - 1976
N2 - Intermediate filaments, cytoplasmic filaments with a diameter of 8-9 nm, have been described in a large variety of cell types. In this study, the subunit protein of the neurofilament and the presumptive subunit of the astroglial filament are compared by immunological and biochemical methods and are found to be very similar. Strong crossreactions are also found between these proteins in a variety of mammalian species. These results suggest that the intermediate filaments may, like microtubules and microfilaments, represent a highly conserved and widely distributed fibrous protein system.
AB - Intermediate filaments, cytoplasmic filaments with a diameter of 8-9 nm, have been described in a large variety of cell types. In this study, the subunit protein of the neurofilament and the presumptive subunit of the astroglial filament are compared by immunological and biochemical methods and are found to be very similar. Strong crossreactions are also found between these proteins in a variety of mammalian species. These results suggest that the intermediate filaments may, like microtubules and microfilaments, represent a highly conserved and widely distributed fibrous protein system.
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U2 - 10.1073/pnas.73.2.529
DO - 10.1073/pnas.73.2.529
M3 - Article
C2 - 54920
AN - SCOPUS:0017261127
SN - 0027-8424
VL - 73
SP - 529
EP - 533
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 2
ER -