Biochemical studies of H-2K antigens from a group of related mutants. II. Identification of a shared mutation in B6-H-2bm6, B6.C-H-2bm7, and B6.C-H-2bm9

Karen M. Yamaga, Gertrude M. Pfaffenbach, Larry R Pease, Diane Mc Governs, Tosiki Nisizawa, Roger W. Melvold, Henry I. Kohn, Stanley G. Nathenson

Research output: Contribution to journalArticle

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Abstract

In an earlier paper, we presented evidence that two independent mutants of the bg series, B6-H-2bm5 (bm5) and B6-H-2bm16 (bm16) carry identical mutations such that tyrosine at residue number 17 of the H-2Kb molecule from the parent strain C57BL/6Kh is replaced by a phenylalanine in each of the two mutant molecules. In this paper, we demonstrate, using similar techniques, that the independent bg series mutants B6-H-2bm6 (bm6), B6.C-H-2bm7 (bm7), and B6.C-H-2bm9 (bm9), which share biological properties with bm5 and bm16, can be grouped together because they share two identical mutations, one of which is common to bm5 and bm16, a Tyr to Phe interchange at residue number 116. In addition, a second mutation is at residue number 121, where a Cys in the H-2K molecule from B6 is substituted with an Arg in the mutant. Since all of the bg series mutants arose independently and share biological and biochemical characteristics, it is anticipated that study of these mutants lead to some understanding of the high mutation in the Kb molecule.

Original languageEnglish (US)
Pages (from-to)31-41
Number of pages11
JournalImmunogenetics
Volume17
Issue number1
DOIs
StatePublished - 1983
Externally publishedYes

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Mutation
Phenylalanine
Tyrosine
H antigen

ASJC Scopus subject areas

  • Immunology
  • Genetics

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Biochemical studies of H-2K antigens from a group of related mutants. II. Identification of a shared mutation in B6-H-2bm6, B6.C-H-2bm7, and B6.C-H-2bm9 . / Yamaga, Karen M.; Pfaffenbach, Gertrude M.; Pease, Larry R; Mc Governs, Diane; Nisizawa, Tosiki; Melvold, Roger W.; Kohn, Henry I.; Nathenson, Stanley G.

In: Immunogenetics, Vol. 17, No. 1, 1983, p. 31-41.

Research output: Contribution to journalArticle

Yamaga, Karen M. ; Pfaffenbach, Gertrude M. ; Pease, Larry R ; Mc Governs, Diane ; Nisizawa, Tosiki ; Melvold, Roger W. ; Kohn, Henry I. ; Nathenson, Stanley G. / Biochemical studies of H-2K antigens from a group of related mutants. II. Identification of a shared mutation in B6-H-2bm6, B6.C-H-2bm7, and B6.C-H-2bm9 In: Immunogenetics. 1983 ; Vol. 17, No. 1. pp. 31-41.
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abstract = "In an earlier paper, we presented evidence that two independent mutants of the bg series, B6-H-2bm5 (bm5) and B6-H-2bm16 (bm16) carry identical mutations such that tyrosine at residue number 17 of the H-2Kb molecule from the parent strain C57BL/6Kh is replaced by a phenylalanine in each of the two mutant molecules. In this paper, we demonstrate, using similar techniques, that the independent bg series mutants B6-H-2bm6 (bm6), B6.C-H-2bm7 (bm7), and B6.C-H-2bm9 (bm9), which share biological properties with bm5 and bm16, can be grouped together because they share two identical mutations, one of which is common to bm5 and bm16, a Tyr to Phe interchange at residue number 116. In addition, a second mutation is at residue number 121, where a Cys in the H-2K molecule from B6 is substituted with an Arg in the mutant. Since all of the bg series mutants arose independently and share biological and biochemical characteristics, it is anticipated that study of these mutants lead to some understanding of the high mutation in the Kb molecule.",
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