Biochemische marker bei ischämischen und nicht ischämischen myokardschädigungen

Translated title of the contribution: Biochemical markers in ischemic and non-ischemic myocardial damage

Jörg Herrmann, Lothar Volbracht, Michael Haude, Holger Eggebrecht, Nasser Malyar, Klaus Mann, Raimund Erbel

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations

Abstract

Background: Biochemical markers have been an integrative part of non-invasive diagnostic strategies in cardiology for nearly 50 years, experiencing a renascence by the recently acknowledged prognostic potential of cardiac troponins in acute coronary syndromes. Diagnosis: According to the guidelines of the National Academy of Clinical Biochemistry and the International Federation of Clinical Chemistry cardiac troponin T and cardiac troponin I should be considered as the new "gold markers" of ischemic myocardial injury. One characteristic feature of these new markers is the improved diagnostic potential, reflected by the choice of two cut-off values to distinguish minor myocardial injury from acute myocardial infarction. In addition, cardiac troponins allow risk stratification in the clinical setting of acute coronary syndromes: approximately threefold higher mortality rate for patients with rest angina or ST segment elevation and cardiac troponin elevation on admission. Other indications for cardiac marker analysis are monitoring of therapeutic success in case of invasive and non-invasive reperfusion strategies and non-invasive diagnosis of non-ischemic myocardial injury (myocarditis, cardiac contusion and chemotherapy). Conclusion: Biochemical cardiac markers are a useful tool in the diagnosis of both ischemic and non-ischemic myocardial injury. Among these, cardiac troponins seem to become the gold markers for the new millennium.

Translated title of the contributionBiochemical markers in ischemic and non-ischemic myocardial damage
Original languageGerman
Pages (from-to)144-156
Number of pages13
JournalMedizinische Klinik
Volume96
Issue number3
DOIs
StatePublished - Mar 15 2001

Keywords

  • Acute coronary syndrome
  • Cardiac contusion
  • Chemotherapy
  • Congestive heart failure
  • Creatine kinase
  • Myocarditis
  • Myoglobin
  • Pulmonary embolism
  • Troponin I
  • Troponin T

ASJC Scopus subject areas

  • Medicine(all)

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