Biochemical genetics of cathecholamines in humans

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Studies of the effects of inheritance on human catecholamine biosynthetic and metabolic enzymes are reviewed. Genetic polymorphisms have been shown to control the level of the biosynthetic enzyme dopamine β-hydroxylase in serum and the level of the metabolic enzyme catechol-O-methyltransferase in a variety of tissues. Platelet monoamine oxidase, another catecholamine metabolic enzyme, is also under genetic control. These observations help to explain individual differences in response to treatment with catechol drugs and may explain some variations in the function of human catecholamine neurotransmitters. The biochemical genetic approach used to study the enzymes of catecholamine biosynthesis and metabolism could be used to investigate other aspects of adrenergic function and could serve as a model for studies of the effects of inheritance on other human neurotransmitter systems.

Original languageEnglish (US)
Pages (from-to)319-330
Number of pages12
JournalMayo Clinic Proceedings
Volume58
Issue number5
StatePublished - 1983

Fingerprint

Molecular Biology
Catecholamines
Enzymes
Neurotransmitter Agents
Catechol O-Methyltransferase
Monoamine Oxidase
Genetic Polymorphisms
Mixed Function Oxygenases
Individuality
Adrenergic Agents
Dopamine
Blood Platelets
Serum
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Biochemical genetics of cathecholamines in humans. / Weinshilboum, Richard M.

In: Mayo Clinic Proceedings, Vol. 58, No. 5, 1983, p. 319-330.

Research output: Contribution to journalArticle

@article{848804db7afc45d49529947051cb8ef2,
title = "Biochemical genetics of cathecholamines in humans",
abstract = "Studies of the effects of inheritance on human catecholamine biosynthetic and metabolic enzymes are reviewed. Genetic polymorphisms have been shown to control the level of the biosynthetic enzyme dopamine β-hydroxylase in serum and the level of the metabolic enzyme catechol-O-methyltransferase in a variety of tissues. Platelet monoamine oxidase, another catecholamine metabolic enzyme, is also under genetic control. These observations help to explain individual differences in response to treatment with catechol drugs and may explain some variations in the function of human catecholamine neurotransmitters. The biochemical genetic approach used to study the enzymes of catecholamine biosynthesis and metabolism could be used to investigate other aspects of adrenergic function and could serve as a model for studies of the effects of inheritance on other human neurotransmitter systems.",
author = "Weinshilboum, {Richard M}",
year = "1983",
language = "English (US)",
volume = "58",
pages = "319--330",
journal = "Mayo Clinic Proceedings",
issn = "0025-6196",
publisher = "Elsevier Science",
number = "5",

}

TY - JOUR

T1 - Biochemical genetics of cathecholamines in humans

AU - Weinshilboum, Richard M

PY - 1983

Y1 - 1983

N2 - Studies of the effects of inheritance on human catecholamine biosynthetic and metabolic enzymes are reviewed. Genetic polymorphisms have been shown to control the level of the biosynthetic enzyme dopamine β-hydroxylase in serum and the level of the metabolic enzyme catechol-O-methyltransferase in a variety of tissues. Platelet monoamine oxidase, another catecholamine metabolic enzyme, is also under genetic control. These observations help to explain individual differences in response to treatment with catechol drugs and may explain some variations in the function of human catecholamine neurotransmitters. The biochemical genetic approach used to study the enzymes of catecholamine biosynthesis and metabolism could be used to investigate other aspects of adrenergic function and could serve as a model for studies of the effects of inheritance on other human neurotransmitter systems.

AB - Studies of the effects of inheritance on human catecholamine biosynthetic and metabolic enzymes are reviewed. Genetic polymorphisms have been shown to control the level of the biosynthetic enzyme dopamine β-hydroxylase in serum and the level of the metabolic enzyme catechol-O-methyltransferase in a variety of tissues. Platelet monoamine oxidase, another catecholamine metabolic enzyme, is also under genetic control. These observations help to explain individual differences in response to treatment with catechol drugs and may explain some variations in the function of human catecholamine neurotransmitters. The biochemical genetic approach used to study the enzymes of catecholamine biosynthesis and metabolism could be used to investigate other aspects of adrenergic function and could serve as a model for studies of the effects of inheritance on other human neurotransmitter systems.

UR - http://www.scopus.com/inward/record.url?scp=0020644645&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020644645&partnerID=8YFLogxK

M3 - Article

VL - 58

SP - 319

EP - 330

JO - Mayo Clinic Proceedings

JF - Mayo Clinic Proceedings

SN - 0025-6196

IS - 5

ER -