Biochemical evidence for multiple Ia molecules.

C. S. David; W. P. Lafuse; M. Pierres

doi:10.1007/978-1-4684-4394-3_62

Biochemical evidence for multiple Ia molecules.

C. S. David, W. P. Lafuse, M. Pierres

Immunology

Research output: Contribution to journal › Article › peer-review

Abstract

Sequential immunoprecipitation and isoelectric focusing studies using anti-Ia monoclonal antibodies have shown multiple I-A and I-E Ia molecules. These studies suggest that the genes coding for Ia polypeptide chains A alpha, A beta, E beta and E alpha might have undergone further duplication and mutated. This would explain the diversity seen with Ia molecules in their ability to "present" numerous self and non-self antigens for generation of immune response.

Original language	English (US)
Pages (from-to)	569-577
Number of pages	9
Journal	Advances in experimental medicine and biology
Volume	155
DOIs	https://doi.org/10.1007/978-1-4684-4394-3_62
State	Published - 1982

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1007/978-1-4684-4394-3_62

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title = "Biochemical evidence for multiple Ia molecules.",

abstract = "Sequential immunoprecipitation and isoelectric focusing studies using anti-Ia monoclonal antibodies have shown multiple I-A and I-E Ia molecules. These studies suggest that the genes coding for Ia polypeptide chains A alpha, A beta, E beta and E alpha might have undergone further duplication and mutated. This would explain the diversity seen with Ia molecules in their ability to {"}present{"} numerous self and non-self antigens for generation of immune response.",

author = "David, {C. S.} and Lafuse, {W. P.} and M. Pierres",

year = "1982",

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AU - David, C. S.

AU - Lafuse, W. P.

AU - Pierres, M.

PY - 1982

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AB - Sequential immunoprecipitation and isoelectric focusing studies using anti-Ia monoclonal antibodies have shown multiple I-A and I-E Ia molecules. These studies suggest that the genes coding for Ia polypeptide chains A alpha, A beta, E beta and E alpha might have undergone further duplication and mutated. This would explain the diversity seen with Ia molecules in their ability to "present" numerous self and non-self antigens for generation of immune response.

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JO - Advances in Experimental Medicine and Biology

JF - Advances in Experimental Medicine and Biology

ER -

Biochemical evidence for multiple Ia molecules.

Abstract

ASJC Scopus subject areas

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