Biochemical evidence for multiple Ia molecules.

C. S. David, W. P. Lafuse, M. Pierres

Research output: Contribution to journalArticle

Abstract

Sequential immunoprecipitation and isoelectric focusing studies using anti-Ia monoclonal antibodies have shown multiple I-A and I-E Ia molecules. These studies suggest that the genes coding for Ia polypeptide chains A alpha, A beta, E beta and E alpha might have undergone further duplication and mutated. This would explain the diversity seen with Ia molecules in their ability to "present" numerous self and non-self antigens for generation of immune response.

Original languageEnglish (US)
Pages (from-to)569-577
Number of pages9
JournalAdvances in experimental medicine and biology
Volume155
DOIs
StatePublished - 1982

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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