Bioavailability of phylloquinone from an intravenous lipid emulsion

Maria E. Camilo, Aminah Jatoi, Maureen O'Brien, Kenneth Davidson, Lori Sokoll, James A. Sadowski, Joel B. Mason

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

This randomized, controlled study evaluated the bioavailability of phylloquinone from an intravenous lipid emulsion. A mild vitamin K deficiency was induced in 12 healthy adult men and women by dietary restriction of phylloquinone (40 μg/d, days 1-11) and by administration of warfarin (1.0 mg/d, days 5-11). On day 11, subjects received a 500-mL intravenous solution of either lipid or saline, both of which contained 154 μg phylloquinone. Bioavailability was assessed by serial measurements of plasma phylloquinone, vitamin K1-2,3-epoxide, PIVKA-II (proteins induced by vitamin K absence or antagonists-II), and percentage undercarboxylated osteocalcin. As a result of vitamin K deficiency and minidose warfarin, vitamin K1-2,3-epoxide, PIVKA- II, and percentage undercarboxylated osteocalcin increased significantly between days 1 and 11 (P = 0.05, 0.016, and 0.001, respectively). With the infusions, plasma phylloquinone increased in both groups (P = 0.001). After the infusions vitamin K1-2,3-epoxide decreased in both groups (P = 0.002). Changes in plasma phylloquinone and vitamin K1-2,3-epoxide were no different in the two groups (mean areas under the curves ± SEM: 116 ± 13 nmol · h/L for the saline group and 102 ± 20 nmol · h/L for the lipid group for phylloquinone; 38.6 ± 7.5 nmol · h/L for the saline group and 31.3 ± 9.0 nmol · h/L for the lipid group for vitamin K1-2,3-epoxide). PIVKA-II decreased significantly from baseline values (P = 0.005) in both groups after the infusions. Intravenous lipid reversed the effects of minidose warfarin and of dietary restriction of phylloquinone on hemostasis and vitamin K nutritional status. This reversal was no different from that seen with the infusion of phylloquinone in a saline solution.

Original languageEnglish (US)
Pages (from-to)716-721
Number of pages6
JournalAmerican Journal of Clinical Nutrition
Volume67
Issue number4
DOIs
StatePublished - Jan 1 1998

Keywords

  • Adults
  • Bioavailability
  • Lipid emulsions
  • Osteolcalcin
  • Parenteral nutrition
  • Phylloquinone
  • Vitamin K
  • Warfarin

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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    Camilo, M. E., Jatoi, A., O'Brien, M., Davidson, K., Sokoll, L., Sadowski, J. A., & Mason, J. B. (1998). Bioavailability of phylloquinone from an intravenous lipid emulsion. American Journal of Clinical Nutrition, 67(4), 716-721. https://doi.org/10.1093/ajcn/67.4.716