Bioactive-Tissue-Derived Nanocomposite Hydrogel for Permanent Arterial Embolization and Enhanced Vascular Healing

Jingjie Hu, Izzet Altun, Zefu Zhang, Hassan Albadawi, Marcela A. Salomao, Joseph L. Mayer, L. P.Madhubhani P. Hemachandra, Suliman Rehman, Rahmi Oklu

Research output: Contribution to journalArticle

Abstract

Transcatheter embolization is a minimally invasive procedure that uses embolic agents to intentionally block diseased or injured blood vessels for therapeutic purposes. Embolic agents in clinical practice are limited by recanalization, risk of non-target embolization, failure in coagulopathic patients, high cost, and toxicity. Here, a decellularized cardiac extracellular matrix (ECM)-based nanocomposite hydrogel is developed to provide superior mechanical stability, catheter injectability, retrievability, antibacterial properties, and biological activity to prevent recanalization. The embolic efficacy of the shear-thinning ECM-based hydrogel is shown in a porcine survival model of embolization in the iliac artery and the renal artery. The ECM-based hydrogel promotes arterial vessel wall remodeling and a fibroinflammatory response while undergoing significant biodegradation such that only 25% of the embolic material remains at 14 days. With its unprecedented proregenerative, antibacterial properties coupled with favorable mechanical properties, and its superior performance in anticoagulated blood, the ECM-based hydrogel has the potential to be a next-generation biofunctional embolic agent that can successfully treat a wide range of vascular diseases.

Original languageEnglish (US)
Article number2002611
JournalAdvanced Materials
Volume32
Issue number33
DOIs
StatePublished - Aug 1 2020

Keywords

  • decellularized extracellular matrix
  • embolization
  • hybrid nanocomposite hydrogels
  • transcatheter delivery
  • vascular remodeling

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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