Bio-coordination of bismuth in Helicobacter pylori revealed by immobilized metal affinity chromatography

Yuchuan Wang; Cheuk Nam Tsang; Feng Xu; Pak Wing Kong; Ligang Hu; Junwen Wang; Ivan Keung Chu; Hongyan Li; Hongzhe Sun

doi:10.1039/c5cc04958j

Bio-coordination of bismuth in Helicobacter pylori revealed by immobilized metal affinity chromatography

Yuchuan Wang, Cheuk Nam Tsang, Feng Xu, Pak Wing Kong, Ligang Hu, Junwen Wang, Ivan Keung Chu, Hongyan Li, Hongzhe Sun

Research

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Over 300 Bi-binding peptides from 166 proteins in H. pylori were identified by Bi-IMAC. Bi³⁺ exhibits high selectivity towards peptide enriched by cysteines and histidines with dominated motif patterns of CX_nC, CX_nH and HX_nH. Structural rationalization and functional categorization on the identified Bi-binding peptides and proteins provide an insight into the inhibitory action of bismuth drugs.

Original language	English (US)
Pages (from-to)	16479-16482
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	92
DOIs	https://doi.org/10.1039/c5cc04958j
State	Published - 2015

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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title = "Bio-coordination of bismuth in Helicobacter pylori revealed by immobilized metal affinity chromatography",

abstract = "Over 300 Bi-binding peptides from 166 proteins in H. pylori were identified by Bi-IMAC. Bi3+ exhibits high selectivity towards peptide enriched by cysteines and histidines with dominated motif patterns of CXnC, CXnH and HXnH. Structural rationalization and functional categorization on the identified Bi-binding peptides and proteins provide an insight into the inhibitory action of bismuth drugs.",

author = "Yuchuan Wang and Tsang, {Cheuk Nam} and Feng Xu and Kong, {Pak Wing} and Ligang Hu and Junwen Wang and Chu, {Ivan Keung} and Hongyan Li and Hongzhe Sun",

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language = "English (US)",

volume = "51",

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T1 - Bio-coordination of bismuth in Helicobacter pylori revealed by immobilized metal affinity chromatography

AU - Wang, Yuchuan

AU - Tsang, Cheuk Nam

AU - Xu, Feng

AU - Kong, Pak Wing

AU - Hu, Ligang

AU - Wang, Junwen

AU - Chu, Ivan Keung

AU - Li, Hongyan

AU - Sun, Hongzhe

PY - 2015

Y1 - 2015

N2 - Over 300 Bi-binding peptides from 166 proteins in H. pylori were identified by Bi-IMAC. Bi3+ exhibits high selectivity towards peptide enriched by cysteines and histidines with dominated motif patterns of CXnC, CXnH and HXnH. Structural rationalization and functional categorization on the identified Bi-binding peptides and proteins provide an insight into the inhibitory action of bismuth drugs.

AB - Over 300 Bi-binding peptides from 166 proteins in H. pylori were identified by Bi-IMAC. Bi3+ exhibits high selectivity towards peptide enriched by cysteines and histidines with dominated motif patterns of CXnC, CXnH and HXnH. Structural rationalization and functional categorization on the identified Bi-binding peptides and proteins provide an insight into the inhibitory action of bismuth drugs.

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JO - Chemical Communications

JF - Chemical Communications

IS - 92

ER -

Bio-coordination of bismuth in Helicobacter pylori revealed by immobilized metal affinity chromatography

Abstract

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