Bio-coordination of bismuth in Helicobacter pylori revealed by immobilized metal affinity chromatography

Yuchuan Wang, Cheuk Nam Tsang, Feng Xu, Pak Wing Kong, Ligang Hu, Junwen Wang, Ivan Keung Chu, Hongyan Li, Hongzhe Sun

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Over 300 Bi-binding peptides from 166 proteins in H. pylori were identified by Bi-IMAC. Bi3+ exhibits high selectivity towards peptide enriched by cysteines and histidines with dominated motif patterns of CXnC, CXnH and HXnH. Structural rationalization and functional categorization on the identified Bi-binding peptides and proteins provide an insight into the inhibitory action of bismuth drugs.

Original languageEnglish (US)
Pages (from-to)16479-16482
Number of pages4
JournalChemical Communications
Volume51
Issue number92
DOIs
StatePublished - 2015
Externally publishedYes

Fingerprint

Affinity chromatography
Bismuth
Affinity Chromatography
Helicobacter pylori
Peptides
Metals
Proteins
Histidine
Cysteine
Carrier Proteins
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Ceramics and Composites
  • Electronic, Optical and Magnetic Materials
  • Surfaces, Coatings and Films
  • Materials Chemistry
  • Metals and Alloys
  • Medicine(all)

Cite this

Bio-coordination of bismuth in Helicobacter pylori revealed by immobilized metal affinity chromatography. / Wang, Yuchuan; Tsang, Cheuk Nam; Xu, Feng; Kong, Pak Wing; Hu, Ligang; Wang, Junwen; Chu, Ivan Keung; Li, Hongyan; Sun, Hongzhe.

In: Chemical Communications, Vol. 51, No. 92, 2015, p. 16479-16482.

Research output: Contribution to journalArticle

Wang, Y, Tsang, CN, Xu, F, Kong, PW, Hu, L, Wang, J, Chu, IK, Li, H & Sun, H 2015, 'Bio-coordination of bismuth in Helicobacter pylori revealed by immobilized metal affinity chromatography', Chemical Communications, vol. 51, no. 92, pp. 16479-16482. https://doi.org/10.1039/c5cc04958j
Wang, Yuchuan ; Tsang, Cheuk Nam ; Xu, Feng ; Kong, Pak Wing ; Hu, Ligang ; Wang, Junwen ; Chu, Ivan Keung ; Li, Hongyan ; Sun, Hongzhe. / Bio-coordination of bismuth in Helicobacter pylori revealed by immobilized metal affinity chromatography. In: Chemical Communications. 2015 ; Vol. 51, No. 92. pp. 16479-16482.
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