Bio-coordination of bismuth in Helicobacter pylori revealed by immobilized metal affinity chromatography

Yuchuan Wang, Cheuk Nam Tsang, Feng Xu, Pak Wing Kong, Ligang Hu, Junwen Wang, Ivan Keung Chu, Hongyan Li, Hongzhe Sun

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Over 300 Bi-binding peptides from 166 proteins in H. pylori were identified by Bi-IMAC. Bi3+ exhibits high selectivity towards peptide enriched by cysteines and histidines with dominated motif patterns of CXnC, CXnH and HXnH. Structural rationalization and functional categorization on the identified Bi-binding peptides and proteins provide an insight into the inhibitory action of bismuth drugs.

Original languageEnglish (US)
Pages (from-to)16479-16482
Number of pages4
JournalChemical Communications
Volume51
Issue number92
DOIs
StatePublished - 2015

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • General Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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