Bim is an independent prognostic marker in intrahepatic cholangiocarcinoma

Henan Zhang, Sarah M. Jenkins, Chuang Ta Lee, Susan M. Harrington, Zhuogang Liu, Haidong M Dong, Lizhi Zhang

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver malignant tumor and has a poor prognosis. The prognostic factors associated with outcome remain poorly defined. In this study, we investigated the role of an important cell apoptosis initiator, Bcl-2 interacting mediator of cell death (Bim), by evaluating its expression and association with other clinicopathological features in ICCs. We analyzed 56 cases of ICC with clinical follow-up. The expression of Bim in ICC cells and other cellular components was evaluated by immunohistochemistry. Bim expression was considered up-regulated if Bim was detected in 10% or more of tumor cells. Of the 56 ICC samples, 19 (34%) had high Bim expression level, 15 (27%) were completely negative, and 22 (39%) were classified as low Bim expression (<10% positivity). Patients who had tumors with high Bim level had significantly longer overall survival than did those with low or no staining (median survival, 7.6 versus 2.6 years; hazard ratio, 0.40; P =.006). High Bim expression was also correlated with low Ki-67 index, and more importantly, none of the tumors with high Bim expression had lymph node metastases at the time of surgery. Our study demonstrates that Bim is an important and independent prognostic factor in ICC. Tumors with high Bim expression are associated with better prognosis through inhibiting tumor cell proliferation and metastatic ability. The development of new agents directly or indirectly targeting Bim may provide promising anticancer treatments.

Original languageEnglish (US)
Pages (from-to)97-105
Number of pages9
JournalHuman Pathology
Volume78
DOIs
StatePublished - Aug 1 2018

Fingerprint

Cholangiocarcinoma
Neoplasms
Survival
Lymph Nodes
Immunohistochemistry
Cell Proliferation
Apoptosis
Staining and Labeling
Neoplasm Metastasis
Liver

Keywords

  • Bim
  • Immunohistochemistry
  • Intrahepatic cholangiocarcinoma
  • Liver
  • Prognosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Bim is an independent prognostic marker in intrahepatic cholangiocarcinoma. / Zhang, Henan; Jenkins, Sarah M.; Lee, Chuang Ta; Harrington, Susan M.; Liu, Zhuogang; Dong, Haidong M; Zhang, Lizhi.

In: Human Pathology, Vol. 78, 01.08.2018, p. 97-105.

Research output: Contribution to journalArticle

Zhang, Henan ; Jenkins, Sarah M. ; Lee, Chuang Ta ; Harrington, Susan M. ; Liu, Zhuogang ; Dong, Haidong M ; Zhang, Lizhi. / Bim is an independent prognostic marker in intrahepatic cholangiocarcinoma. In: Human Pathology. 2018 ; Vol. 78. pp. 97-105.
@article{dbed440c277b4ca497133c9f889d608b,
title = "Bim is an independent prognostic marker in intrahepatic cholangiocarcinoma",
abstract = "Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver malignant tumor and has a poor prognosis. The prognostic factors associated with outcome remain poorly defined. In this study, we investigated the role of an important cell apoptosis initiator, Bcl-2 interacting mediator of cell death (Bim), by evaluating its expression and association with other clinicopathological features in ICCs. We analyzed 56 cases of ICC with clinical follow-up. The expression of Bim in ICC cells and other cellular components was evaluated by immunohistochemistry. Bim expression was considered up-regulated if Bim was detected in 10{\%} or more of tumor cells. Of the 56 ICC samples, 19 (34{\%}) had high Bim expression level, 15 (27{\%}) were completely negative, and 22 (39{\%}) were classified as low Bim expression (<10{\%} positivity). Patients who had tumors with high Bim level had significantly longer overall survival than did those with low or no staining (median survival, 7.6 versus 2.6 years; hazard ratio, 0.40; P =.006). High Bim expression was also correlated with low Ki-67 index, and more importantly, none of the tumors with high Bim expression had lymph node metastases at the time of surgery. Our study demonstrates that Bim is an important and independent prognostic factor in ICC. Tumors with high Bim expression are associated with better prognosis through inhibiting tumor cell proliferation and metastatic ability. The development of new agents directly or indirectly targeting Bim may provide promising anticancer treatments.",
keywords = "Bim, Immunohistochemistry, Intrahepatic cholangiocarcinoma, Liver, Prognosis",
author = "Henan Zhang and Jenkins, {Sarah M.} and Lee, {Chuang Ta} and Harrington, {Susan M.} and Zhuogang Liu and Dong, {Haidong M} and Lizhi Zhang",
year = "2018",
month = "8",
day = "1",
doi = "10.1016/j.humpath.2018.04.009",
language = "English (US)",
volume = "78",
pages = "97--105",
journal = "Human Pathology",
issn = "0046-8177",
publisher = "W.B. Saunders Ltd",

}

TY - JOUR

T1 - Bim is an independent prognostic marker in intrahepatic cholangiocarcinoma

AU - Zhang, Henan

AU - Jenkins, Sarah M.

AU - Lee, Chuang Ta

AU - Harrington, Susan M.

AU - Liu, Zhuogang

AU - Dong, Haidong M

AU - Zhang, Lizhi

PY - 2018/8/1

Y1 - 2018/8/1

N2 - Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver malignant tumor and has a poor prognosis. The prognostic factors associated with outcome remain poorly defined. In this study, we investigated the role of an important cell apoptosis initiator, Bcl-2 interacting mediator of cell death (Bim), by evaluating its expression and association with other clinicopathological features in ICCs. We analyzed 56 cases of ICC with clinical follow-up. The expression of Bim in ICC cells and other cellular components was evaluated by immunohistochemistry. Bim expression was considered up-regulated if Bim was detected in 10% or more of tumor cells. Of the 56 ICC samples, 19 (34%) had high Bim expression level, 15 (27%) were completely negative, and 22 (39%) were classified as low Bim expression (<10% positivity). Patients who had tumors with high Bim level had significantly longer overall survival than did those with low or no staining (median survival, 7.6 versus 2.6 years; hazard ratio, 0.40; P =.006). High Bim expression was also correlated with low Ki-67 index, and more importantly, none of the tumors with high Bim expression had lymph node metastases at the time of surgery. Our study demonstrates that Bim is an important and independent prognostic factor in ICC. Tumors with high Bim expression are associated with better prognosis through inhibiting tumor cell proliferation and metastatic ability. The development of new agents directly or indirectly targeting Bim may provide promising anticancer treatments.

AB - Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver malignant tumor and has a poor prognosis. The prognostic factors associated with outcome remain poorly defined. In this study, we investigated the role of an important cell apoptosis initiator, Bcl-2 interacting mediator of cell death (Bim), by evaluating its expression and association with other clinicopathological features in ICCs. We analyzed 56 cases of ICC with clinical follow-up. The expression of Bim in ICC cells and other cellular components was evaluated by immunohistochemistry. Bim expression was considered up-regulated if Bim was detected in 10% or more of tumor cells. Of the 56 ICC samples, 19 (34%) had high Bim expression level, 15 (27%) were completely negative, and 22 (39%) were classified as low Bim expression (<10% positivity). Patients who had tumors with high Bim level had significantly longer overall survival than did those with low or no staining (median survival, 7.6 versus 2.6 years; hazard ratio, 0.40; P =.006). High Bim expression was also correlated with low Ki-67 index, and more importantly, none of the tumors with high Bim expression had lymph node metastases at the time of surgery. Our study demonstrates that Bim is an important and independent prognostic factor in ICC. Tumors with high Bim expression are associated with better prognosis through inhibiting tumor cell proliferation and metastatic ability. The development of new agents directly or indirectly targeting Bim may provide promising anticancer treatments.

KW - Bim

KW - Immunohistochemistry

KW - Intrahepatic cholangiocarcinoma

KW - Liver

KW - Prognosis

UR - http://www.scopus.com/inward/record.url?scp=85048857157&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85048857157&partnerID=8YFLogxK

U2 - 10.1016/j.humpath.2018.04.009

DO - 10.1016/j.humpath.2018.04.009

M3 - Article

C2 - 29698699

AN - SCOPUS:85048857157

VL - 78

SP - 97

EP - 105

JO - Human Pathology

JF - Human Pathology

SN - 0046-8177

ER -