Bilirubin conjugation in a three compartment hollow fiber bioreactor

Scott L. Nyberg, Russell A. Shatford, Frank B. Cerra, Wei Shou Hu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

A new hollow fiber bioreactor for potential support of patients in liver failure is presented. In this bioreactor, hepatocytes are entrapped in a three-dimensional collagen gel-matrix. Cells may be cultured at tissue density within this bioreactor. Metabolic criteria of viability included glucose and oxygen consumption. Bilirubin conjugation, a specific and clinically sensitive measure of hepatocyte function, was 0.14 pg/cell/hr in this system.

Original languageEnglish (US)
Title of host publicationBiomedical Engineering Perspectives
Subtitle of host publicationHealth Care Technologies for the 1990's and Beyond
PublisherPubl by IEEE
Pages443-444
Number of pages2
Editionpt 1
ISBN (Print)0879425598
StatePublished - Dec 1 1990
EventProceedings of the 12th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Philadelphia, PA, USA
Duration: Nov 1 1990Nov 4 1990

Publication series

NameProceedings of the Annual Conference on Engineering in Medicine and Biology
Numberpt 1
ISSN (Print)0589-1019

Other

OtherProceedings of the 12th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
CityPhiladelphia, PA, USA
Period11/1/9011/4/90

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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  • Cite this

    Nyberg, S. L., Shatford, R. A., Cerra, F. B., & Hu, W. S. (1990). Bilirubin conjugation in a three compartment hollow fiber bioreactor. In Biomedical Engineering Perspectives: Health Care Technologies for the 1990's and Beyond (pt 1 ed., pp. 443-444). (Proceedings of the Annual Conference on Engineering in Medicine and Biology; No. pt 1). Publ by IEEE.