Abstract
A duodenal perfusion technique which permitted a normal daytime eating pattern of 3 liquid meals and an overnight fast was used to measure the 24 hr output of copper in bile in 19 studies in 14 persons with normal hepatic and gallbladder function. Daily biliary output was also determined by direct measurement on four 24 hr bile collections obtained from 3 patients with complete biliary diversion, and in 4 patients measurements of dietary copper intake and fecal copper output were also made. A mean bile copper output of 25 ± 13 μg/kg/day (1.7 mg ± 0.8) (mean ± SD) was obtained in 19 perfusion studies; the range was 9.0 to 53.0 μg/kg/day. The values in the 24 hr bile collections were similar to those obtained using the perfusion method. Biliary copper output was similar during the day and night, and there was no correlation between hourly rates of copper output and hourly rates of bile acid output, nor was there any correlation between daily copper output and daily bile acid output. The similar values for dietary intake, biliary output, and fecal output provide additional support for the current view that in healthy man copper balance is maintained by biliary secretion and subsequent fecal excretion of copper which has been absorbed in the stomach and proximal duodenum.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1228-1231 |
| Number of pages | 4 |
| Journal | Gastroenterology |
| Volume | 72 |
| Issue number | 6 |
| State | Published - 1977 |
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ASJC Scopus subject areas
- Gastroenterology
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Biliary secretion of copper in healthy man. Quantitation by an intestinal perfusion technique. / van Berge Henegouwen, G. P.; Tangedahl, T. N.; Hofmann, A. F.; Northfield, T. C.; La Russo, Nicholas F; McCall, J. T.
In: Gastroenterology, Vol. 72, No. 6, 1977, p. 1228-1231.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Biliary secretion of copper in healthy man. Quantitation by an intestinal perfusion technique
AU - van Berge Henegouwen, G. P.
AU - Tangedahl, T. N.
AU - Hofmann, A. F.
AU - Northfield, T. C.
AU - La Russo, Nicholas F
AU - McCall, J. T.
PY - 1977
Y1 - 1977
N2 - A duodenal perfusion technique which permitted a normal daytime eating pattern of 3 liquid meals and an overnight fast was used to measure the 24 hr output of copper in bile in 19 studies in 14 persons with normal hepatic and gallbladder function. Daily biliary output was also determined by direct measurement on four 24 hr bile collections obtained from 3 patients with complete biliary diversion, and in 4 patients measurements of dietary copper intake and fecal copper output were also made. A mean bile copper output of 25 ± 13 μg/kg/day (1.7 mg ± 0.8) (mean ± SD) was obtained in 19 perfusion studies; the range was 9.0 to 53.0 μg/kg/day. The values in the 24 hr bile collections were similar to those obtained using the perfusion method. Biliary copper output was similar during the day and night, and there was no correlation between hourly rates of copper output and hourly rates of bile acid output, nor was there any correlation between daily copper output and daily bile acid output. The similar values for dietary intake, biliary output, and fecal output provide additional support for the current view that in healthy man copper balance is maintained by biliary secretion and subsequent fecal excretion of copper which has been absorbed in the stomach and proximal duodenum.
AB - A duodenal perfusion technique which permitted a normal daytime eating pattern of 3 liquid meals and an overnight fast was used to measure the 24 hr output of copper in bile in 19 studies in 14 persons with normal hepatic and gallbladder function. Daily biliary output was also determined by direct measurement on four 24 hr bile collections obtained from 3 patients with complete biliary diversion, and in 4 patients measurements of dietary copper intake and fecal copper output were also made. A mean bile copper output of 25 ± 13 μg/kg/day (1.7 mg ± 0.8) (mean ± SD) was obtained in 19 perfusion studies; the range was 9.0 to 53.0 μg/kg/day. The values in the 24 hr bile collections were similar to those obtained using the perfusion method. Biliary copper output was similar during the day and night, and there was no correlation between hourly rates of copper output and hourly rates of bile acid output, nor was there any correlation between daily copper output and daily bile acid output. The similar values for dietary intake, biliary output, and fecal output provide additional support for the current view that in healthy man copper balance is maintained by biliary secretion and subsequent fecal excretion of copper which has been absorbed in the stomach and proximal duodenum.
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UR - http://www.scopus.com/inward/citedby.url?scp=0017370622&partnerID=8YFLogxK
M3 - Article
C2 - 870371
AN - SCOPUS:0017370622
VL - 72
SP - 1228
EP - 1231
JO - Gastroenterology
JF - Gastroenterology
SN - 0016-5085
IS - 6
ER -