Biliary secretion of copper in healthy man. Quantitation by an intestinal perfusion technique

G. P. van Berge Henegouwen, T. N. Tangedahl, A. F. Hofmann, T. C. Northfield, Nicholas F La Russo, J. T. McCall

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

A duodenal perfusion technique which permitted a normal daytime eating pattern of 3 liquid meals and an overnight fast was used to measure the 24 hr output of copper in bile in 19 studies in 14 persons with normal hepatic and gallbladder function. Daily biliary output was also determined by direct measurement on four 24 hr bile collections obtained from 3 patients with complete biliary diversion, and in 4 patients measurements of dietary copper intake and fecal copper output were also made. A mean bile copper output of 25 ± 13 μg/kg/day (1.7 mg ± 0.8) (mean ± SD) was obtained in 19 perfusion studies; the range was 9.0 to 53.0 μg/kg/day. The values in the 24 hr bile collections were similar to those obtained using the perfusion method. Biliary copper output was similar during the day and night, and there was no correlation between hourly rates of copper output and hourly rates of bile acid output, nor was there any correlation between daily copper output and daily bile acid output. The similar values for dietary intake, biliary output, and fecal output provide additional support for the current view that in healthy man copper balance is maintained by biliary secretion and subsequent fecal excretion of copper which has been absorbed in the stomach and proximal duodenum.

Original languageEnglish (US)
Pages (from-to)1228-1231
Number of pages4
JournalGastroenterology
Volume72
Issue number6
StatePublished - 1977

Fingerprint

Copper
Perfusion
Bile
Bile Acids and Salts
Gallbladder
Duodenum
Meals
Stomach
Eating
Liver

ASJC Scopus subject areas

  • Gastroenterology

Cite this

van Berge Henegouwen, G. P., Tangedahl, T. N., Hofmann, A. F., Northfield, T. C., La Russo, N. F., & McCall, J. T. (1977). Biliary secretion of copper in healthy man. Quantitation by an intestinal perfusion technique. Gastroenterology, 72(6), 1228-1231.

Biliary secretion of copper in healthy man. Quantitation by an intestinal perfusion technique. / van Berge Henegouwen, G. P.; Tangedahl, T. N.; Hofmann, A. F.; Northfield, T. C.; La Russo, Nicholas F; McCall, J. T.

In: Gastroenterology, Vol. 72, No. 6, 1977, p. 1228-1231.

Research output: Contribution to journalArticle

van Berge Henegouwen, GP, Tangedahl, TN, Hofmann, AF, Northfield, TC, La Russo, NF & McCall, JT 1977, 'Biliary secretion of copper in healthy man. Quantitation by an intestinal perfusion technique', Gastroenterology, vol. 72, no. 6, pp. 1228-1231.
van Berge Henegouwen GP, Tangedahl TN, Hofmann AF, Northfield TC, La Russo NF, McCall JT. Biliary secretion of copper in healthy man. Quantitation by an intestinal perfusion technique. Gastroenterology. 1977;72(6):1228-1231.
van Berge Henegouwen, G. P. ; Tangedahl, T. N. ; Hofmann, A. F. ; Northfield, T. C. ; La Russo, Nicholas F ; McCall, J. T. / Biliary secretion of copper in healthy man. Quantitation by an intestinal perfusion technique. In: Gastroenterology. 1977 ; Vol. 72, No. 6. pp. 1228-1231.
@article{db57f50a42ae419b8d18622675e40ad0,
title = "Biliary secretion of copper in healthy man. Quantitation by an intestinal perfusion technique",
abstract = "A duodenal perfusion technique which permitted a normal daytime eating pattern of 3 liquid meals and an overnight fast was used to measure the 24 hr output of copper in bile in 19 studies in 14 persons with normal hepatic and gallbladder function. Daily biliary output was also determined by direct measurement on four 24 hr bile collections obtained from 3 patients with complete biliary diversion, and in 4 patients measurements of dietary copper intake and fecal copper output were also made. A mean bile copper output of 25 ± 13 μg/kg/day (1.7 mg ± 0.8) (mean ± SD) was obtained in 19 perfusion studies; the range was 9.0 to 53.0 μg/kg/day. The values in the 24 hr bile collections were similar to those obtained using the perfusion method. Biliary copper output was similar during the day and night, and there was no correlation between hourly rates of copper output and hourly rates of bile acid output, nor was there any correlation between daily copper output and daily bile acid output. The similar values for dietary intake, biliary output, and fecal output provide additional support for the current view that in healthy man copper balance is maintained by biliary secretion and subsequent fecal excretion of copper which has been absorbed in the stomach and proximal duodenum.",
author = "{van Berge Henegouwen}, {G. P.} and Tangedahl, {T. N.} and Hofmann, {A. F.} and Northfield, {T. C.} and {La Russo}, {Nicholas F} and McCall, {J. T.}",
year = "1977",
language = "English (US)",
volume = "72",
pages = "1228--1231",
journal = "Gastroenterology",
issn = "0016-5085",
publisher = "W.B. Saunders Ltd",
number = "6",

}

TY - JOUR

T1 - Biliary secretion of copper in healthy man. Quantitation by an intestinal perfusion technique

AU - van Berge Henegouwen, G. P.

AU - Tangedahl, T. N.

AU - Hofmann, A. F.

AU - Northfield, T. C.

AU - La Russo, Nicholas F

AU - McCall, J. T.

PY - 1977

Y1 - 1977

N2 - A duodenal perfusion technique which permitted a normal daytime eating pattern of 3 liquid meals and an overnight fast was used to measure the 24 hr output of copper in bile in 19 studies in 14 persons with normal hepatic and gallbladder function. Daily biliary output was also determined by direct measurement on four 24 hr bile collections obtained from 3 patients with complete biliary diversion, and in 4 patients measurements of dietary copper intake and fecal copper output were also made. A mean bile copper output of 25 ± 13 μg/kg/day (1.7 mg ± 0.8) (mean ± SD) was obtained in 19 perfusion studies; the range was 9.0 to 53.0 μg/kg/day. The values in the 24 hr bile collections were similar to those obtained using the perfusion method. Biliary copper output was similar during the day and night, and there was no correlation between hourly rates of copper output and hourly rates of bile acid output, nor was there any correlation between daily copper output and daily bile acid output. The similar values for dietary intake, biliary output, and fecal output provide additional support for the current view that in healthy man copper balance is maintained by biliary secretion and subsequent fecal excretion of copper which has been absorbed in the stomach and proximal duodenum.

AB - A duodenal perfusion technique which permitted a normal daytime eating pattern of 3 liquid meals and an overnight fast was used to measure the 24 hr output of copper in bile in 19 studies in 14 persons with normal hepatic and gallbladder function. Daily biliary output was also determined by direct measurement on four 24 hr bile collections obtained from 3 patients with complete biliary diversion, and in 4 patients measurements of dietary copper intake and fecal copper output were also made. A mean bile copper output of 25 ± 13 μg/kg/day (1.7 mg ± 0.8) (mean ± SD) was obtained in 19 perfusion studies; the range was 9.0 to 53.0 μg/kg/day. The values in the 24 hr bile collections were similar to those obtained using the perfusion method. Biliary copper output was similar during the day and night, and there was no correlation between hourly rates of copper output and hourly rates of bile acid output, nor was there any correlation between daily copper output and daily bile acid output. The similar values for dietary intake, biliary output, and fecal output provide additional support for the current view that in healthy man copper balance is maintained by biliary secretion and subsequent fecal excretion of copper which has been absorbed in the stomach and proximal duodenum.

UR - http://www.scopus.com/inward/record.url?scp=0017370622&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017370622&partnerID=8YFLogxK

M3 - Article

C2 - 870371

AN - SCOPUS:0017370622

VL - 72

SP - 1228

EP - 1231

JO - Gastroenterology

JF - Gastroenterology

SN - 0016-5085

IS - 6

ER -