Bile Acids Up-regulate Death Receptor 5/TRAIL-receptor 2 Expression via a c-Jun N-terminal Kinase-dependent Pathway Involving Sp1

Medicine & Life Sciences

• TNF-Related Apoptosis-Inducing Ligand Receptors 100%
• JNK Mitogen-Activated Protein Kinases 80%
• Bile Acids and Salts 74%
• Up-Regulation 51%
• Deoxycholic Acid 26%
• pyrazolanthrone 13%
• Binding Sites 7%
• 5' Flanking Region 6%
• Chromatin Immunoprecipitation 5%
• Electrophoretic Mobility Shift Assay 5%
• Reporter Genes 5%
• Point Mutation 4%
• Hepatocytes 4%
• Transcription Factors 3%
• Apoptosis 3%
• Gene Expression 3%
• Messenger RNA 2%
• Proteins 1%

Chemical Compounds

• Bile Acid 82%
• Deoxycholic Acid 74%
• Sensitizing 22%
• Mutation 15%
• Protein 7%