Abstract
Toxic bile acids facilitate Fas and tumor necrosis factor-associated apoptosis-inducing ligand (TRAIL) death-receptor oligomerization and activation. Bile acid modulation of death-receptor signaling is multifactorial and includes trafficking of Fas to the cell surface, enhancing TRAIL-R2/DR5 expression, and suppression of function of cFLIP, an antiapoptotic protein modulating death-receptor function. Because bile acid-associated death receptor-mediated apoptosis is a common mechanism for cholestatic hepatocyte injury, inhibition of death receptors and their cascades may prove useful in attenuating liver injury during cholestasis.
Original language | English (US) |
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Pages (from-to) | G734-G738 |
Journal | American Journal of Physiology - Gastrointestinal and Liver Physiology |
Volume | 284 |
Issue number | 5 47-5 |
DOIs | |
State | Published - May 1 2003 |
Keywords
- Bid
- Fas
- Tumor necrosis factor-associated apoptosis-inducing ligand
ASJC Scopus subject areas
- Physiology
- Hepatology
- Gastroenterology
- Physiology (medical)