Bilaterally symmetric hippocampi and surgical outcome

Clifford R Jr. Jack, M. R. Trenerry, Gregory D Cascino, F. W. Sharbrough, E. L. So, P. C. O'Brien

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

This study investigates the relationship between hippocampal volume and seizure control following temporal lobectomy in patients with volumetrically symmetric hippocampi. Forty-six patients who underwent temporal lobectomy for nonlesional temporal-lobe-onset seizures, and in whom the volumes of the two hippocampi were roughly equal (ie, the difference of the right minus the left hippocampal volume fell between -0.1 and 0.3 cm3), were included. We graded postoperative seizure control on a four-point scale according to criteria defined by Engel. We found no relationship between the hippocampal sum (sum of the right plus left hippocampal volumes normalized for cranial size) and operative outcome. A satisfactory operative outcome is possible in patients with bilaterally symmetric mesial temporal sclerosis by MRI criteria.

Original languageEnglish (US)
Pages (from-to)1353-1358
Number of pages6
JournalNeurology
Volume45
Issue number7
StatePublished - Jul 1995

Fingerprint

Hippocampus
Seizures
Sclerosis
Temporal Lobe

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Jack, C. R. J., Trenerry, M. R., Cascino, G. D., Sharbrough, F. W., So, E. L., & O'Brien, P. C. (1995). Bilaterally symmetric hippocampi and surgical outcome. Neurology, 45(7), 1353-1358.

Bilaterally symmetric hippocampi and surgical outcome. / Jack, Clifford R Jr.; Trenerry, M. R.; Cascino, Gregory D; Sharbrough, F. W.; So, E. L.; O'Brien, P. C.

In: Neurology, Vol. 45, No. 7, 07.1995, p. 1353-1358.

Research output: Contribution to journalArticle

Jack, CRJ, Trenerry, MR, Cascino, GD, Sharbrough, FW, So, EL & O'Brien, PC 1995, 'Bilaterally symmetric hippocampi and surgical outcome', Neurology, vol. 45, no. 7, pp. 1353-1358.
Jack CRJ, Trenerry MR, Cascino GD, Sharbrough FW, So EL, O'Brien PC. Bilaterally symmetric hippocampi and surgical outcome. Neurology. 1995 Jul;45(7):1353-1358.
Jack, Clifford R Jr. ; Trenerry, M. R. ; Cascino, Gregory D ; Sharbrough, F. W. ; So, E. L. ; O'Brien, P. C. / Bilaterally symmetric hippocampi and surgical outcome. In: Neurology. 1995 ; Vol. 45, No. 7. pp. 1353-1358.
@article{c040df1315994a28a0b431ee04397a4c,
title = "Bilaterally symmetric hippocampi and surgical outcome",
abstract = "This study investigates the relationship between hippocampal volume and seizure control following temporal lobectomy in patients with volumetrically symmetric hippocampi. Forty-six patients who underwent temporal lobectomy for nonlesional temporal-lobe-onset seizures, and in whom the volumes of the two hippocampi were roughly equal (ie, the difference of the right minus the left hippocampal volume fell between -0.1 and 0.3 cm3), were included. We graded postoperative seizure control on a four-point scale according to criteria defined by Engel. We found no relationship between the hippocampal sum (sum of the right plus left hippocampal volumes normalized for cranial size) and operative outcome. A satisfactory operative outcome is possible in patients with bilaterally symmetric mesial temporal sclerosis by MRI criteria.",
author = "Jack, {Clifford R Jr.} and Trenerry, {M. R.} and Cascino, {Gregory D} and Sharbrough, {F. W.} and So, {E. L.} and O'Brien, {P. C.}",
year = "1995",
month = "7",
language = "English (US)",
volume = "45",
pages = "1353--1358",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "7",

}

TY - JOUR

T1 - Bilaterally symmetric hippocampi and surgical outcome

AU - Jack, Clifford R Jr.

AU - Trenerry, M. R.

AU - Cascino, Gregory D

AU - Sharbrough, F. W.

AU - So, E. L.

AU - O'Brien, P. C.

PY - 1995/7

Y1 - 1995/7

N2 - This study investigates the relationship between hippocampal volume and seizure control following temporal lobectomy in patients with volumetrically symmetric hippocampi. Forty-six patients who underwent temporal lobectomy for nonlesional temporal-lobe-onset seizures, and in whom the volumes of the two hippocampi were roughly equal (ie, the difference of the right minus the left hippocampal volume fell between -0.1 and 0.3 cm3), were included. We graded postoperative seizure control on a four-point scale according to criteria defined by Engel. We found no relationship between the hippocampal sum (sum of the right plus left hippocampal volumes normalized for cranial size) and operative outcome. A satisfactory operative outcome is possible in patients with bilaterally symmetric mesial temporal sclerosis by MRI criteria.

AB - This study investigates the relationship between hippocampal volume and seizure control following temporal lobectomy in patients with volumetrically symmetric hippocampi. Forty-six patients who underwent temporal lobectomy for nonlesional temporal-lobe-onset seizures, and in whom the volumes of the two hippocampi were roughly equal (ie, the difference of the right minus the left hippocampal volume fell between -0.1 and 0.3 cm3), were included. We graded postoperative seizure control on a four-point scale according to criteria defined by Engel. We found no relationship between the hippocampal sum (sum of the right plus left hippocampal volumes normalized for cranial size) and operative outcome. A satisfactory operative outcome is possible in patients with bilaterally symmetric mesial temporal sclerosis by MRI criteria.

UR - http://www.scopus.com/inward/record.url?scp=0029115043&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029115043&partnerID=8YFLogxK

M3 - Article

C2 - 7617197

AN - SCOPUS:0029115043

VL - 45

SP - 1353

EP - 1358

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 7

ER -