Bilateral Oophorectomy and Accelerated Aging: Cause or Effect?

Walter A Rocca, Liliana Gazzuola Rocca, Carin Y. Smith, Brandon R. Grossardt, Stephanie S. Faubion, Lynne T. Shuster, James L Kirkland, Elizabeth A Stewart, Virginia M Miller

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background: The cause-effect relationship between bilateral oophorectomy and accelerated aging remains controversial. We conducted new analyses to further address this controversy.

Methods: The Rochester Epidemiology Project records-linkage system was used to identify all premenopausal women who underwent bilateral oophorectomy for a noncancerous condition before age 50 years between 1988 and 2007 in Olmsted County, MN. Each woman was randomly matched to a referent woman born in the same year (±1 year) who had not undergone bilateral oophorectomy. We studied the rate of accumulation of 18 common chronic conditions over a median of approximately 14 years of follow-up (historical cohort study). Analyses were restricted to women free of any of the 18 chronic conditions at the time of oophorectomy (or index date).

Results: After adjustments for race/ethnicity, education, body mass index, smoking, and age and calendar year at the index date, women who underwent oophorectomy before age 46 years experienced an accelerated rate of accumulation of the 18 chronic conditions considered together (hazard ratio = 1.24; 95% confidence interval: 1.12, 1.37; p < .001). The single-year incidence rate of new conditions was most different in the first 6 years after oophorectomy but the difference attenuated thereafter. Findings did not vary by surgical indication for the oophorectomy.

Conclusions: Bilateral oophorectomy is associated with a higher risk of multimorbidity among women who did not have any of the 18 selected conditions at baseline. The association did not vary by surgical indication for oophorectomy. Our findings suggest that bilateral oophorectomy is causally linked to accelerated aging.

Original languageEnglish (US)
Pages (from-to)1213-1217
Number of pages5
JournalThe journals of gerontology. Series A, Biological sciences and medical sciences
Volume72
Issue number9
DOIs
StatePublished - Sep 1 2017

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Ovariectomy
Comorbidity
Epidemiology
Body Mass Index
Cohort Studies
Smoking
Confidence Intervals
Education
Incidence

Keywords

  • Accelerated aging
  • Bilateral oophorectomy
  • Cohort study
  • Estrogen therapy
  • Multimorbidity

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Cite this

Bilateral Oophorectomy and Accelerated Aging : Cause or Effect? / Rocca, Walter A; Gazzuola Rocca, Liliana; Smith, Carin Y.; Grossardt, Brandon R.; Faubion, Stephanie S.; Shuster, Lynne T.; Kirkland, James L; Stewart, Elizabeth A; Miller, Virginia M.

In: The journals of gerontology. Series A, Biological sciences and medical sciences, Vol. 72, No. 9, 01.09.2017, p. 1213-1217.

Research output: Contribution to journalArticle

Rocca, Walter A ; Gazzuola Rocca, Liliana ; Smith, Carin Y. ; Grossardt, Brandon R. ; Faubion, Stephanie S. ; Shuster, Lynne T. ; Kirkland, James L ; Stewart, Elizabeth A ; Miller, Virginia M. / Bilateral Oophorectomy and Accelerated Aging : Cause or Effect?. In: The journals of gerontology. Series A, Biological sciences and medical sciences. 2017 ; Vol. 72, No. 9. pp. 1213-1217.
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abstract = "Background: The cause-effect relationship between bilateral oophorectomy and accelerated aging remains controversial. We conducted new analyses to further address this controversy.Methods: The Rochester Epidemiology Project records-linkage system was used to identify all premenopausal women who underwent bilateral oophorectomy for a noncancerous condition before age 50 years between 1988 and 2007 in Olmsted County, MN. Each woman was randomly matched to a referent woman born in the same year (±1 year) who had not undergone bilateral oophorectomy. We studied the rate of accumulation of 18 common chronic conditions over a median of approximately 14 years of follow-up (historical cohort study). Analyses were restricted to women free of any of the 18 chronic conditions at the time of oophorectomy (or index date).Results: After adjustments for race/ethnicity, education, body mass index, smoking, and age and calendar year at the index date, women who underwent oophorectomy before age 46 years experienced an accelerated rate of accumulation of the 18 chronic conditions considered together (hazard ratio = 1.24; 95{\%} confidence interval: 1.12, 1.37; p < .001). The single-year incidence rate of new conditions was most different in the first 6 years after oophorectomy but the difference attenuated thereafter. Findings did not vary by surgical indication for the oophorectomy.Conclusions: Bilateral oophorectomy is associated with a higher risk of multimorbidity among women who did not have any of the 18 selected conditions at baseline. The association did not vary by surgical indication for oophorectomy. Our findings suggest that bilateral oophorectomy is causally linked to accelerated aging.",
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T1 - Bilateral Oophorectomy and Accelerated Aging

T2 - Cause or Effect?

AU - Rocca, Walter A

AU - Gazzuola Rocca, Liliana

AU - Smith, Carin Y.

AU - Grossardt, Brandon R.

AU - Faubion, Stephanie S.

AU - Shuster, Lynne T.

AU - Kirkland, James L

AU - Stewart, Elizabeth A

AU - Miller, Virginia M

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N2 - Background: The cause-effect relationship between bilateral oophorectomy and accelerated aging remains controversial. We conducted new analyses to further address this controversy.Methods: The Rochester Epidemiology Project records-linkage system was used to identify all premenopausal women who underwent bilateral oophorectomy for a noncancerous condition before age 50 years between 1988 and 2007 in Olmsted County, MN. Each woman was randomly matched to a referent woman born in the same year (±1 year) who had not undergone bilateral oophorectomy. We studied the rate of accumulation of 18 common chronic conditions over a median of approximately 14 years of follow-up (historical cohort study). Analyses were restricted to women free of any of the 18 chronic conditions at the time of oophorectomy (or index date).Results: After adjustments for race/ethnicity, education, body mass index, smoking, and age and calendar year at the index date, women who underwent oophorectomy before age 46 years experienced an accelerated rate of accumulation of the 18 chronic conditions considered together (hazard ratio = 1.24; 95% confidence interval: 1.12, 1.37; p < .001). The single-year incidence rate of new conditions was most different in the first 6 years after oophorectomy but the difference attenuated thereafter. Findings did not vary by surgical indication for the oophorectomy.Conclusions: Bilateral oophorectomy is associated with a higher risk of multimorbidity among women who did not have any of the 18 selected conditions at baseline. The association did not vary by surgical indication for oophorectomy. Our findings suggest that bilateral oophorectomy is causally linked to accelerated aging.

AB - Background: The cause-effect relationship between bilateral oophorectomy and accelerated aging remains controversial. We conducted new analyses to further address this controversy.Methods: The Rochester Epidemiology Project records-linkage system was used to identify all premenopausal women who underwent bilateral oophorectomy for a noncancerous condition before age 50 years between 1988 and 2007 in Olmsted County, MN. Each woman was randomly matched to a referent woman born in the same year (±1 year) who had not undergone bilateral oophorectomy. We studied the rate of accumulation of 18 common chronic conditions over a median of approximately 14 years of follow-up (historical cohort study). Analyses were restricted to women free of any of the 18 chronic conditions at the time of oophorectomy (or index date).Results: After adjustments for race/ethnicity, education, body mass index, smoking, and age and calendar year at the index date, women who underwent oophorectomy before age 46 years experienced an accelerated rate of accumulation of the 18 chronic conditions considered together (hazard ratio = 1.24; 95% confidence interval: 1.12, 1.37; p < .001). The single-year incidence rate of new conditions was most different in the first 6 years after oophorectomy but the difference attenuated thereafter. Findings did not vary by surgical indication for the oophorectomy.Conclusions: Bilateral oophorectomy is associated with a higher risk of multimorbidity among women who did not have any of the 18 selected conditions at baseline. The association did not vary by surgical indication for oophorectomy. Our findings suggest that bilateral oophorectomy is causally linked to accelerated aging.

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KW - Cohort study

KW - Estrogen therapy

KW - Multimorbidity

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DO - 10.1093/gerona/glx026

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