Bilateral iris tumors in an immunosuppressed child

Michael C. Brodsky, Helen Casteel, Laurie D. Barber, Morris Kletzl, Gary J. Roloson

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

A seven-year-old iatrogenically immunosuppressed girl developed simultaneous bilateral iris tumors associated with granulomatous iridocyclitis, splenomegaly, and an immunoblastic pleocytosis. Serologic studies suggested a current active Epstein-Barr virus infection. Tumor biopsy showed a polyclonal plasmacytoid lymphoproliferative process, establishing the diagnosis of posttransplant lymphoproliferative disorder. Low-dose local irradiation produced rapid and complete iris tumor regression with restoration of vision in both eyes. To our knowledge, this is the first report of ocular involvement in posttransplant lymphoproliferative disorder.

Original languageEnglish (US)
Pages (from-to)217-222
Number of pages6
JournalSurvey of ophthalmology
Volume36
Issue number3
DOIs
StatePublished - Dec 1991

Keywords

  • Epstein-Barr virus
  • cyclosporin A
  • immune disorders
  • iris tumors
  • posttransplant lymphoproliferative disorders

ASJC Scopus subject areas

  • Ophthalmology

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