Bilateral iris tumors in an immunosuppressed child

Michael C. Brodsky; Helen Casteel; Laurie D. Barber; Morris Kletzl; Gary J. Roloson

doi:10.1016/0039-6257(91)90004-Y

Bilateral iris tumors in an immunosuppressed child

Michael C. Brodsky, Helen Casteel, Laurie D. Barber, Morris Kletzl, Gary J. Roloson

Ophthalmology

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

A seven-year-old iatrogenically immunosuppressed girl developed simultaneous bilateral iris tumors associated with granulomatous iridocyclitis, splenomegaly, and an immunoblastic pleocytosis. Serologic studies suggested a current active Epstein-Barr virus infection. Tumor biopsy showed a polyclonal plasmacytoid lymphoproliferative process, establishing the diagnosis of posttransplant lymphoproliferative disorder. Low-dose local irradiation produced rapid and complete iris tumor regression with restoration of vision in both eyes. To our knowledge, this is the first report of ocular involvement in posttransplant lymphoproliferative disorder.

Original language	English (US)
Pages (from-to)	217-222
Number of pages	6
Journal	Survey of ophthalmology
Volume	36
Issue number	3
DOIs	https://doi.org/10.1016/0039-6257(91)90004-Y
State	Published - Dec 1991

Keywords

Epstein-Barr virus
cyclosporin A
immune disorders
iris tumors
posttransplant lymphoproliferative disorders

ASJC Scopus subject areas

Ophthalmology

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10.1016/0039-6257(91)90004-Y

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title = "Bilateral iris tumors in an immunosuppressed child",

abstract = "A seven-year-old iatrogenically immunosuppressed girl developed simultaneous bilateral iris tumors associated with granulomatous iridocyclitis, splenomegaly, and an immunoblastic pleocytosis. Serologic studies suggested a current active Epstein-Barr virus infection. Tumor biopsy showed a polyclonal plasmacytoid lymphoproliferative process, establishing the diagnosis of posttransplant lymphoproliferative disorder. Low-dose local irradiation produced rapid and complete iris tumor regression with restoration of vision in both eyes. To our knowledge, this is the first report of ocular involvement in posttransplant lymphoproliferative disorder.",

keywords = "Epstein-Barr virus, cyclosporin A, immune disorders, iris tumors, posttransplant lymphoproliferative disorders",

author = "Brodsky, {Michael C.} and Helen Casteel and Barber, {Laurie D.} and Morris Kletzl and Roloson, {Gary J.}",

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T1 - Bilateral iris tumors in an immunosuppressed child

AU - Brodsky, Michael C.

AU - Casteel, Helen

AU - Barber, Laurie D.

AU - Kletzl, Morris

AU - Roloson, Gary J.

PY - 1991/12

Y1 - 1991/12

N2 - A seven-year-old iatrogenically immunosuppressed girl developed simultaneous bilateral iris tumors associated with granulomatous iridocyclitis, splenomegaly, and an immunoblastic pleocytosis. Serologic studies suggested a current active Epstein-Barr virus infection. Tumor biopsy showed a polyclonal plasmacytoid lymphoproliferative process, establishing the diagnosis of posttransplant lymphoproliferative disorder. Low-dose local irradiation produced rapid and complete iris tumor regression with restoration of vision in both eyes. To our knowledge, this is the first report of ocular involvement in posttransplant lymphoproliferative disorder.

AB - A seven-year-old iatrogenically immunosuppressed girl developed simultaneous bilateral iris tumors associated with granulomatous iridocyclitis, splenomegaly, and an immunoblastic pleocytosis. Serologic studies suggested a current active Epstein-Barr virus infection. Tumor biopsy showed a polyclonal plasmacytoid lymphoproliferative process, establishing the diagnosis of posttransplant lymphoproliferative disorder. Low-dose local irradiation produced rapid and complete iris tumor regression with restoration of vision in both eyes. To our knowledge, this is the first report of ocular involvement in posttransplant lymphoproliferative disorder.

KW - Epstein-Barr virus

KW - cyclosporin A

KW - immune disorders

KW - iris tumors

KW - posttransplant lymphoproliferative disorders

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Bilateral iris tumors in an immunosuppressed child

Abstract

Keywords

ASJC Scopus subject areas

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