Bilateral autoimmune optic neuritis and vitreitis related to CRMP-5-IgG: Intravitreal triamcinolone acetonide therapy of four eyes

Jose S Pulido, S. A. Cross, Vanda A Lennon, D. Swanson, M. Muench, Daniel H Lachance

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Purpose: To report the vision outcome following intravitreal triamcinolone acetonide (IVTA) as adjunctive therapy in four eyes of two patients with paraneoplastic autoimmune optic neuritis and vitreitis related to CRMP (Collapsin-Response-Mediator Protein)-5-IgG. Design: Retrospective case series. Methods: Chart review of four eyes. Results: Preoperative visions were: patient 1, 20/50 OD, 20/25 OS; patient 2, counting fingers (CF) at two feet OD, and CF at three feet OS. At last follow-up, the postoperative visions were 20/40, 20/50 and 20/200, 20/60, respectively. All signs of optic disc swelling and vitreitis had abated. Conclusions: Use of IVTA in paraneoplastic autoimmune optic neuritis and vitreitis related to CRMP-5-IgG was followed by a marked decrease in inflammation and stabilization or improvement of vision. These observations support this form of adjunctive therapy in patients whose intraocular pathology is attributed to paraneoplastic autoimmunity.

Original languageEnglish (US)
Pages (from-to)1191-1193
Number of pages3
JournalEye
Volume22
Issue number9
DOIs
StatePublished - 2008

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Semaphorin-3A
Triamcinolone Acetonide
Optic Neuritis
Immunoglobulin G
Fingers
Proteins
Optic Disk
Therapeutics
Autoimmunity
Pathology
Inflammation

ASJC Scopus subject areas

  • Ophthalmology

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Bilateral autoimmune optic neuritis and vitreitis related to CRMP-5-IgG : Intravitreal triamcinolone acetonide therapy of four eyes. / Pulido, Jose S; Cross, S. A.; Lennon, Vanda A; Swanson, D.; Muench, M.; Lachance, Daniel H.

In: Eye, Vol. 22, No. 9, 2008, p. 1191-1193.

Research output: Contribution to journalArticle

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