TY - JOUR
T1 - Bilateral autoimmune optic neuritis and vitreitis related to CRMP-5-IgG
T2 - Intravitreal triamcinolone acetonide therapy of four eyes
AU - Pulido, J.
AU - Cross, S. A.
AU - Lennon, V. A.
AU - Swanson, D.
AU - Muench, M.
AU - Lachance, D. H.
PY - 2008
Y1 - 2008
N2 - Purpose: To report the vision outcome following intravitreal triamcinolone acetonide (IVTA) as adjunctive therapy in four eyes of two patients with paraneoplastic autoimmune optic neuritis and vitreitis related to CRMP (Collapsin-Response-Mediator Protein)-5-IgG. Design: Retrospective case series. Methods: Chart review of four eyes. Results: Preoperative visions were: patient 1, 20/50 OD, 20/25 OS; patient 2, counting fingers (CF) at two feet OD, and CF at three feet OS. At last follow-up, the postoperative visions were 20/40, 20/50 and 20/200, 20/60, respectively. All signs of optic disc swelling and vitreitis had abated. Conclusions: Use of IVTA in paraneoplastic autoimmune optic neuritis and vitreitis related to CRMP-5-IgG was followed by a marked decrease in inflammation and stabilization or improvement of vision. These observations support this form of adjunctive therapy in patients whose intraocular pathology is attributed to paraneoplastic autoimmunity.
AB - Purpose: To report the vision outcome following intravitreal triamcinolone acetonide (IVTA) as adjunctive therapy in four eyes of two patients with paraneoplastic autoimmune optic neuritis and vitreitis related to CRMP (Collapsin-Response-Mediator Protein)-5-IgG. Design: Retrospective case series. Methods: Chart review of four eyes. Results: Preoperative visions were: patient 1, 20/50 OD, 20/25 OS; patient 2, counting fingers (CF) at two feet OD, and CF at three feet OS. At last follow-up, the postoperative visions were 20/40, 20/50 and 20/200, 20/60, respectively. All signs of optic disc swelling and vitreitis had abated. Conclusions: Use of IVTA in paraneoplastic autoimmune optic neuritis and vitreitis related to CRMP-5-IgG was followed by a marked decrease in inflammation and stabilization or improvement of vision. These observations support this form of adjunctive therapy in patients whose intraocular pathology is attributed to paraneoplastic autoimmunity.
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U2 - 10.1038/sj.eye.6702959
DO - 10.1038/sj.eye.6702959
M3 - Article
C2 - 17721501
AN - SCOPUS:52149087510
SN - 0950-222X
VL - 22
SP - 1191
EP - 1193
JO - Eye
JF - Eye
IS - 9
ER -