Abstract
RNA genomes evolve largely on the basis of single point mutations introduced by imprecise RNA polymerases, or by recombination. Clusters of certain transitions (biased hypermutations) were detected first in the genomes of persistent viruses, and in the past year have also been found in the genomes of lytic RNA viruses. A cellular RNA-modifying enzyme probably introduces the clustered transitions and thus contributes to the evolution of RNA viruses.
Original language | English (US) |
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Pages (from-to) | 895-900 |
Number of pages | 6 |
Journal | Current Opinion in Genetics and Development |
Volume | 4 |
Issue number | 6 |
DOIs | |
State | Published - Dec 1994 |
ASJC Scopus subject areas
- Genetics
- Developmental Biology