Bias Observed in Time-of-Flight Shear Wave Speed Measurements Using Radiation Force of a Focused Ultrasound Beam

Heng Zhao, Pengfei Song, Matthew W Urban, Randall R. Kinnick, Meng Yin, James F Greenleaf, S. Chen Shigao

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Measurement of shear wave propagation speed has important clinical applications because it is related to tissue stiffness and health state. Shear waves can be generated in tissues by the radiation force of a focused ultrasound beam (push beam). Shear wave speed can be measured by tracking its propagation laterally from the push beam focus using the time-of-flight principle. This study shows that shear wave speed measurements with such methods can be transducer, depth and lateral tracking range dependent. Three homogeneous phantoms with different stiffness were studied using curvilinear and linear array transducer. Shear wave speed measurements were made at different depths, using different aperture sizes for push and at different lateral distance ranges from the push beam. The curvilinear transducer shows a relatively large measurement bias that is depth dependent. The possible causes of the bias and options for correction are discussed. These bias errors must be taken into account to provide accurate and precise time-of-flight shear wave speed measurements for clinical use.

Original languageEnglish (US)
Pages (from-to)1884-1892
Number of pages9
JournalUltrasound in Medicine and Biology
Volume37
Issue number11
DOIs
StatePublished - Nov 2011

Fingerprint

radiation measurement
Transducers
S waves
Radiation
transducers
stiffness
Health
linear arrays
health
wave propagation
apertures
propagation
causes
radiation

Keywords

  • ARFI
  • Bias
  • Liver fibrosis
  • Shear wave speed

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Biophysics

Cite this

Bias Observed in Time-of-Flight Shear Wave Speed Measurements Using Radiation Force of a Focused Ultrasound Beam. / Zhao, Heng; Song, Pengfei; Urban, Matthew W; Kinnick, Randall R.; Yin, Meng; Greenleaf, James F; Chen Shigao, S.

In: Ultrasound in Medicine and Biology, Vol. 37, No. 11, 11.2011, p. 1884-1892.

Research output: Contribution to journalArticle

@article{b442cfb2de334ee981dc044ac7e45c04,
title = "Bias Observed in Time-of-Flight Shear Wave Speed Measurements Using Radiation Force of a Focused Ultrasound Beam",
abstract = "Measurement of shear wave propagation speed has important clinical applications because it is related to tissue stiffness and health state. Shear waves can be generated in tissues by the radiation force of a focused ultrasound beam (push beam). Shear wave speed can be measured by tracking its propagation laterally from the push beam focus using the time-of-flight principle. This study shows that shear wave speed measurements with such methods can be transducer, depth and lateral tracking range dependent. Three homogeneous phantoms with different stiffness were studied using curvilinear and linear array transducer. Shear wave speed measurements were made at different depths, using different aperture sizes for push and at different lateral distance ranges from the push beam. The curvilinear transducer shows a relatively large measurement bias that is depth dependent. The possible causes of the bias and options for correction are discussed. These bias errors must be taken into account to provide accurate and precise time-of-flight shear wave speed measurements for clinical use.",
keywords = "ARFI, Bias, Liver fibrosis, Shear wave speed",
author = "Heng Zhao and Pengfei Song and Urban, {Matthew W} and Kinnick, {Randall R.} and Meng Yin and Greenleaf, {James F} and {Chen Shigao}, S.",
year = "2011",
month = "11",
doi = "10.1016/j.ultrasmedbio.2011.07.012",
language = "English (US)",
volume = "37",
pages = "1884--1892",
journal = "Ultrasound in Medicine and Biology",
issn = "0301-5629",
publisher = "Elsevier USA",
number = "11",

}

TY - JOUR

T1 - Bias Observed in Time-of-Flight Shear Wave Speed Measurements Using Radiation Force of a Focused Ultrasound Beam

AU - Zhao, Heng

AU - Song, Pengfei

AU - Urban, Matthew W

AU - Kinnick, Randall R.

AU - Yin, Meng

AU - Greenleaf, James F

AU - Chen Shigao, S.

PY - 2011/11

Y1 - 2011/11

N2 - Measurement of shear wave propagation speed has important clinical applications because it is related to tissue stiffness and health state. Shear waves can be generated in tissues by the radiation force of a focused ultrasound beam (push beam). Shear wave speed can be measured by tracking its propagation laterally from the push beam focus using the time-of-flight principle. This study shows that shear wave speed measurements with such methods can be transducer, depth and lateral tracking range dependent. Three homogeneous phantoms with different stiffness were studied using curvilinear and linear array transducer. Shear wave speed measurements were made at different depths, using different aperture sizes for push and at different lateral distance ranges from the push beam. The curvilinear transducer shows a relatively large measurement bias that is depth dependent. The possible causes of the bias and options for correction are discussed. These bias errors must be taken into account to provide accurate and precise time-of-flight shear wave speed measurements for clinical use.

AB - Measurement of shear wave propagation speed has important clinical applications because it is related to tissue stiffness and health state. Shear waves can be generated in tissues by the radiation force of a focused ultrasound beam (push beam). Shear wave speed can be measured by tracking its propagation laterally from the push beam focus using the time-of-flight principle. This study shows that shear wave speed measurements with such methods can be transducer, depth and lateral tracking range dependent. Three homogeneous phantoms with different stiffness were studied using curvilinear and linear array transducer. Shear wave speed measurements were made at different depths, using different aperture sizes for push and at different lateral distance ranges from the push beam. The curvilinear transducer shows a relatively large measurement bias that is depth dependent. The possible causes of the bias and options for correction are discussed. These bias errors must be taken into account to provide accurate and precise time-of-flight shear wave speed measurements for clinical use.

KW - ARFI

KW - Bias

KW - Liver fibrosis

KW - Shear wave speed

UR - http://www.scopus.com/inward/record.url?scp=80054771069&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80054771069&partnerID=8YFLogxK

U2 - 10.1016/j.ultrasmedbio.2011.07.012

DO - 10.1016/j.ultrasmedbio.2011.07.012

M3 - Article

C2 - 21924817

AN - SCOPUS:80054771069

VL - 37

SP - 1884

EP - 1892

JO - Ultrasound in Medicine and Biology

JF - Ultrasound in Medicine and Biology

SN - 0301-5629

IS - 11

ER -