TY - JOUR
T1 - Beyond vasodilatation
T2 - non-vasomotor roles of epoxyeicosatrienoic acids in the cardiovascular system
AU - Larsen, Brandon T.
AU - Campbell, William B.
AU - Gutterman, David D.
N1 - Funding Information:
This work was supported by a Predoctoral Fellowship Award from the American Heart Association (to B.T.L.), a Veterans Administration Merit Award (to D.D.G.) and grants from the National Institutes of Health (HL-68769 to D.D.G., HL-51055 and HL-83297 to W.B.C.).
Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2007/1
Y1 - 2007/1
N2 - Epoxyeicosatrienoic acids (EETs), derived from arachidonic acid by cytochrome P450 epoxygenases, are potent vasodilators that function as endothelium-derived hyperpolarizing factors in some vascular beds. EETs are rapidly metabolized by soluble epoxide hydrolase to form dihydroxyeicosatrienoic acids (DHETs). Recent reports indicate that EETs have several important non-vasomotor regulatory roles in the cardiovascular system. EETs are potent anti-inflammatory agents and might function as endogenous anti-atherogenic compounds. In addition, EETs and DHETs might stimulate lipid metabolism and regulate insulin sensitivity. Thus, pharmacological inhibition of soluble epoxide hydrolase might be useful not only for hypertension but also for abating atherosclerosis, diabetes mellitus and the metabolic syndrome. Finally, although usually protective in the systemic circulation, EETs might adversely affect the pulmonary circulation.
AB - Epoxyeicosatrienoic acids (EETs), derived from arachidonic acid by cytochrome P450 epoxygenases, are potent vasodilators that function as endothelium-derived hyperpolarizing factors in some vascular beds. EETs are rapidly metabolized by soluble epoxide hydrolase to form dihydroxyeicosatrienoic acids (DHETs). Recent reports indicate that EETs have several important non-vasomotor regulatory roles in the cardiovascular system. EETs are potent anti-inflammatory agents and might function as endogenous anti-atherogenic compounds. In addition, EETs and DHETs might stimulate lipid metabolism and regulate insulin sensitivity. Thus, pharmacological inhibition of soluble epoxide hydrolase might be useful not only for hypertension but also for abating atherosclerosis, diabetes mellitus and the metabolic syndrome. Finally, although usually protective in the systemic circulation, EETs might adversely affect the pulmonary circulation.
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U2 - 10.1016/j.tips.2006.11.002
DO - 10.1016/j.tips.2006.11.002
M3 - Review article
C2 - 17150260
AN - SCOPUS:33845944050
SN - 0165-6147
VL - 28
SP - 32
EP - 38
JO - Trends in Pharmacological Sciences
JF - Trends in Pharmacological Sciences
IS - 1
ER -