TY - JOUR
T1 - Beyond the paclitaxel and vinca alkaloids
T2 - Next generation of plant-derived microtubule-targeting agents with potential anticancer activity
AU - Zhang, Dangquan
AU - Kanakkanthara, Arun
N1 - Funding Information:
“This research was funded by the talent project of Henan Agriculture University, China, to D.Z. and a Foundation for Women’s Cancer Genentech Ovarian Cancer Young Investigator Career Development Award to A.K. The APC was funded by the talent project of Henan Agriculture University, China, to D.Z. Acknowledgments: The authors apologize to the many colleagues whose excellent publications could not be cited in this manuscript because of the space limitations. We also thank Elsevier/Cell Press as well as Michel O. Steinmetz and Andrea E. Prota for granting the permission to reuse the image (Figure 1 in this manuscript) showing the binding sites of MTAs on tubulin that they presented in their review article, Microtubule-targeting agents: Strategies to hijack the cytoskeleton, published in Trends in Cell Biology, 2018, 28(10):776–792.
Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2020/7
Y1 - 2020/7
N2 - Plants are an important source of chemically diverse natural products that target microtubules, one of the most successful targets in cancer therapy. Colchicine, paclitaxel, and vinca alkaloids are the earliest plant-derived microtubule-targeting agents (MTAs), and paclitaxel and vinca alkaloids are currently important drugs used in the treatment of cancer. Several additional plant-derived compounds that act on microtubules with improved anticancer activity are at varying stages of development. Here, we move beyond the well-discussed paclitaxel and vinca alkaloids to present other promising plant-derived MTAs with potential for development as anticancer agents. Various biological and biochemical aspects are discussed. We hope that the review will provide guidance for further exploration and identification of more effective, novel MTAs derived from plant sources.
AB - Plants are an important source of chemically diverse natural products that target microtubules, one of the most successful targets in cancer therapy. Colchicine, paclitaxel, and vinca alkaloids are the earliest plant-derived microtubule-targeting agents (MTAs), and paclitaxel and vinca alkaloids are currently important drugs used in the treatment of cancer. Several additional plant-derived compounds that act on microtubules with improved anticancer activity are at varying stages of development. Here, we move beyond the well-discussed paclitaxel and vinca alkaloids to present other promising plant-derived MTAs with potential for development as anticancer agents. Various biological and biochemical aspects are discussed. We hope that the review will provide guidance for further exploration and identification of more effective, novel MTAs derived from plant sources.
KW - Microtubule destabilizing agents
KW - Microtubule stabilizing agents
KW - Microtubule-targeting agents
KW - Tubulin binding site
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U2 - 10.3390/cancers12071721
DO - 10.3390/cancers12071721
M3 - Review article
AN - SCOPUS:85087131822
SN - 2072-6694
VL - 12
SP - 1
EP - 23
JO - Cancers
JF - Cancers
IS - 7
M1 - 1721
ER -