Beyond the paclitaxel and vinca alkaloids: Next generation of plant-derived microtubule-targeting agents with potential anticancer activity

Dangquan Zhang, Arun Kanakkanthara

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Plants are an important source of chemically diverse natural products that target microtubules, one of the most successful targets in cancer therapy. Colchicine, paclitaxel, and vinca alkaloids are the earliest plant-derived microtubule-targeting agents (MTAs), and paclitaxel and vinca alkaloids are currently important drugs used in the treatment of cancer. Several additional plant-derived compounds that act on microtubules with improved anticancer activity are at varying stages of development. Here, we move beyond the well-discussed paclitaxel and vinca alkaloids to present other promising plant-derived MTAs with potential for development as anticancer agents. Various biological and biochemical aspects are discussed. We hope that the review will provide guidance for further exploration and identification of more effective, novel MTAs derived from plant sources.

Original languageEnglish (US)
Article number1721
Pages (from-to)1-23
Number of pages23
JournalCancers
Volume12
Issue number7
DOIs
StatePublished - Jul 2020

Keywords

  • Microtubule destabilizing agents
  • Microtubule stabilizing agents
  • Microtubule-targeting agents
  • Tubulin binding site

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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