Beyond pain in fibromyalgia: Insights into the symptom of fatigue

Ann Vincent, Roberto P Benzo, Mary O. Whipple, Samantha J. McAllister, Patricia J. Erwin, Leorey N. Saligan

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Fatigue is a disabling, multifaceted symptom that is highly prevalent and stubbornly persistent. Although fatigue is a frequent complaint among patients with fibromyalgia, it has not received the same attention as pain. Reasons for this include lack of standardized nomenclature to communicate about fatigue, lack of evidence-based guidelines for fatigue assessment, and a deficiency in effective treatment strategies. Fatigue does not occur in isolation; rather, it is present concurrently in varying severity with other fibromyalgia symptoms such as chronic widespread pain, unrefreshing sleep, anxiety, depression, cognitive difficulties, and so on. Survey-based and preliminary mechanistic studies indicate that multiple symptoms feed into fatigue and it may be associated with a variety of physiological mechanisms. Therefore, fatigue assessment in clinical and research settings must consider this multi-dimensionality. While no clinical trial to date has specifically targeted fatigue, randomized controlled trials, systematic reviews, and meta-analyses indicate that treatment modalities studied in the context of other fibromyalgia symptoms could also improve fatigue. The Outcome Measures in Rheumatology (OMERACT) Fibromyalgia Working Group and the Patient Reported Outcomes Measurement Information System (PROMIS) have been instrumental in propelling the study of fatigue in fibromyalgia to the forefront. The ongoing efforts by PROMIS to develop a brief fibromyalgia-specific fatigue measure for use in clinical and research settings will help define fatigue, allow for better assessment, and advance our understanding of fatigue.

Original languageEnglish (US)
Article number221
JournalArthritis Research and Therapy
Volume15
Issue number6
DOIs
StatePublished - Nov 29 2013

Fingerprint

Fibromyalgia
Fatigue
Pain
Information Systems
Rheumatology
Research
Terminology
Chronic Pain
Meta-Analysis
Sleep
Anxiety
Randomized Controlled Trials

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy
  • Medicine(all)

Cite this

Vincent, A., Benzo, R. P., Whipple, M. O., McAllister, S. J., Erwin, P. J., & Saligan, L. N. (2013). Beyond pain in fibromyalgia: Insights into the symptom of fatigue. Arthritis Research and Therapy, 15(6), [221]. https://doi.org/10.1186/ar4395

Beyond pain in fibromyalgia : Insights into the symptom of fatigue. / Vincent, Ann; Benzo, Roberto P; Whipple, Mary O.; McAllister, Samantha J.; Erwin, Patricia J.; Saligan, Leorey N.

In: Arthritis Research and Therapy, Vol. 15, No. 6, 221, 29.11.2013.

Research output: Contribution to journalArticle

Vincent, A, Benzo, RP, Whipple, MO, McAllister, SJ, Erwin, PJ & Saligan, LN 2013, 'Beyond pain in fibromyalgia: Insights into the symptom of fatigue', Arthritis Research and Therapy, vol. 15, no. 6, 221. https://doi.org/10.1186/ar4395
Vincent, Ann ; Benzo, Roberto P ; Whipple, Mary O. ; McAllister, Samantha J. ; Erwin, Patricia J. ; Saligan, Leorey N. / Beyond pain in fibromyalgia : Insights into the symptom of fatigue. In: Arthritis Research and Therapy. 2013 ; Vol. 15, No. 6.
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