Beyond 1 year after liver transplantation

A. Eid, R. Steffen, M. K. Porayko, T. R. Beers, D. E. Kaese, R. H. Wiesner, R. A F Krom

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

We retrospectively reviewed the long-term results in 46 patients who survived at least 1 year after liver transplantation. Only one death has occurred, and one patient has required retransplantation. Biochemical liver function tests showed median values in the normal range, except for mild elevation of serum γ-glutamyltransferase. In patients with primary biliary cirrhosis, these test results were completely normal. A liver biopsy 1 year after transplantation disclosed normal histologic findings in 31 patients (67%). The other patients had either transient (acute rejection) or stable (chronic rejection) abnormalities, except for two patients with progressive graft dysfunction attributable to chronic rejection. A clinically significant vascular anastomotic abnormality was noted in one patient who had hepatic artery thrombosis. Late bile duct complications occurred in 15% of patients, all of whom had a satisfactory outcome after surgical or radiologic intervention. Cyclosporine-related nephrotoxicity and hypertension each occurred in 67% of patients; however, conversion to a low-dose cyclosporine-azathioprine regimen yielded stabilization of renal function after the first postoperative year, and hypertension has been easily controlled medically. Diabetes necessitating insulin treatment developed in three patients. The body weight of the study patients had increased by a median of 6.5 kg at 1 year but stabilized thereafter. Subjective well-being and satisfaction with life were reported by 91% of the patients. Of the 46 patients, 26 were employed, 16 were homemakers, and only 4 did not work, 2 because of transplant-related medical problems. Thus, we conclude that liver transplantation rehabilitates patients with end-stage liver disease and enhances their quality of life.

Original languageEnglish (US)
Pages (from-to)446-450
Number of pages5
JournalMayo Clinic Proceedings
Volume64
Issue number4
StatePublished - 1989
Externally publishedYes

Fingerprint

Liver Transplantation
Cyclosporine
Hypertension
Transplants
End Stage Liver Disease
Biliary Liver Cirrhosis
Hepatic Artery
Liver Function Tests
Azathioprine
Bile Ducts
Blood Vessels
Reference Values
Thrombosis
Transplantation
Body Weight
Quality of Life
Insulin

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Eid, A., Steffen, R., Porayko, M. K., Beers, T. R., Kaese, D. E., Wiesner, R. H., & Krom, R. A. F. (1989). Beyond 1 year after liver transplantation. Mayo Clinic Proceedings, 64(4), 446-450.

Beyond 1 year after liver transplantation. / Eid, A.; Steffen, R.; Porayko, M. K.; Beers, T. R.; Kaese, D. E.; Wiesner, R. H.; Krom, R. A F.

In: Mayo Clinic Proceedings, Vol. 64, No. 4, 1989, p. 446-450.

Research output: Contribution to journalArticle

Eid, A, Steffen, R, Porayko, MK, Beers, TR, Kaese, DE, Wiesner, RH & Krom, RAF 1989, 'Beyond 1 year after liver transplantation', Mayo Clinic Proceedings, vol. 64, no. 4, pp. 446-450.
Eid A, Steffen R, Porayko MK, Beers TR, Kaese DE, Wiesner RH et al. Beyond 1 year after liver transplantation. Mayo Clinic Proceedings. 1989;64(4):446-450.
Eid, A. ; Steffen, R. ; Porayko, M. K. ; Beers, T. R. ; Kaese, D. E. ; Wiesner, R. H. ; Krom, R. A F. / Beyond 1 year after liver transplantation. In: Mayo Clinic Proceedings. 1989 ; Vol. 64, No. 4. pp. 446-450.
@article{a5e8addbef224eaeacfed639a5022a7f,
title = "Beyond 1 year after liver transplantation",
abstract = "We retrospectively reviewed the long-term results in 46 patients who survived at least 1 year after liver transplantation. Only one death has occurred, and one patient has required retransplantation. Biochemical liver function tests showed median values in the normal range, except for mild elevation of serum γ-glutamyltransferase. In patients with primary biliary cirrhosis, these test results were completely normal. A liver biopsy 1 year after transplantation disclosed normal histologic findings in 31 patients (67{\%}). The other patients had either transient (acute rejection) or stable (chronic rejection) abnormalities, except for two patients with progressive graft dysfunction attributable to chronic rejection. A clinically significant vascular anastomotic abnormality was noted in one patient who had hepatic artery thrombosis. Late bile duct complications occurred in 15{\%} of patients, all of whom had a satisfactory outcome after surgical or radiologic intervention. Cyclosporine-related nephrotoxicity and hypertension each occurred in 67{\%} of patients; however, conversion to a low-dose cyclosporine-azathioprine regimen yielded stabilization of renal function after the first postoperative year, and hypertension has been easily controlled medically. Diabetes necessitating insulin treatment developed in three patients. The body weight of the study patients had increased by a median of 6.5 kg at 1 year but stabilized thereafter. Subjective well-being and satisfaction with life were reported by 91{\%} of the patients. Of the 46 patients, 26 were employed, 16 were homemakers, and only 4 did not work, 2 because of transplant-related medical problems. Thus, we conclude that liver transplantation rehabilitates patients with end-stage liver disease and enhances their quality of life.",
author = "A. Eid and R. Steffen and Porayko, {M. K.} and Beers, {T. R.} and Kaese, {D. E.} and Wiesner, {R. H.} and Krom, {R. A F}",
year = "1989",
language = "English (US)",
volume = "64",
pages = "446--450",
journal = "Mayo Clinic Proceedings",
issn = "0025-6196",
publisher = "Elsevier Science",
number = "4",

}

TY - JOUR

T1 - Beyond 1 year after liver transplantation

AU - Eid, A.

AU - Steffen, R.

AU - Porayko, M. K.

AU - Beers, T. R.

AU - Kaese, D. E.

AU - Wiesner, R. H.

AU - Krom, R. A F

PY - 1989

Y1 - 1989

N2 - We retrospectively reviewed the long-term results in 46 patients who survived at least 1 year after liver transplantation. Only one death has occurred, and one patient has required retransplantation. Biochemical liver function tests showed median values in the normal range, except for mild elevation of serum γ-glutamyltransferase. In patients with primary biliary cirrhosis, these test results were completely normal. A liver biopsy 1 year after transplantation disclosed normal histologic findings in 31 patients (67%). The other patients had either transient (acute rejection) or stable (chronic rejection) abnormalities, except for two patients with progressive graft dysfunction attributable to chronic rejection. A clinically significant vascular anastomotic abnormality was noted in one patient who had hepatic artery thrombosis. Late bile duct complications occurred in 15% of patients, all of whom had a satisfactory outcome after surgical or radiologic intervention. Cyclosporine-related nephrotoxicity and hypertension each occurred in 67% of patients; however, conversion to a low-dose cyclosporine-azathioprine regimen yielded stabilization of renal function after the first postoperative year, and hypertension has been easily controlled medically. Diabetes necessitating insulin treatment developed in three patients. The body weight of the study patients had increased by a median of 6.5 kg at 1 year but stabilized thereafter. Subjective well-being and satisfaction with life were reported by 91% of the patients. Of the 46 patients, 26 were employed, 16 were homemakers, and only 4 did not work, 2 because of transplant-related medical problems. Thus, we conclude that liver transplantation rehabilitates patients with end-stage liver disease and enhances their quality of life.

AB - We retrospectively reviewed the long-term results in 46 patients who survived at least 1 year after liver transplantation. Only one death has occurred, and one patient has required retransplantation. Biochemical liver function tests showed median values in the normal range, except for mild elevation of serum γ-glutamyltransferase. In patients with primary biliary cirrhosis, these test results were completely normal. A liver biopsy 1 year after transplantation disclosed normal histologic findings in 31 patients (67%). The other patients had either transient (acute rejection) or stable (chronic rejection) abnormalities, except for two patients with progressive graft dysfunction attributable to chronic rejection. A clinically significant vascular anastomotic abnormality was noted in one patient who had hepatic artery thrombosis. Late bile duct complications occurred in 15% of patients, all of whom had a satisfactory outcome after surgical or radiologic intervention. Cyclosporine-related nephrotoxicity and hypertension each occurred in 67% of patients; however, conversion to a low-dose cyclosporine-azathioprine regimen yielded stabilization of renal function after the first postoperative year, and hypertension has been easily controlled medically. Diabetes necessitating insulin treatment developed in three patients. The body weight of the study patients had increased by a median of 6.5 kg at 1 year but stabilized thereafter. Subjective well-being and satisfaction with life were reported by 91% of the patients. Of the 46 patients, 26 were employed, 16 were homemakers, and only 4 did not work, 2 because of transplant-related medical problems. Thus, we conclude that liver transplantation rehabilitates patients with end-stage liver disease and enhances their quality of life.

UR - http://www.scopus.com/inward/record.url?scp=0024523316&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024523316&partnerID=8YFLogxK

M3 - Article

C2 - 2654501

AN - SCOPUS:0024523316

VL - 64

SP - 446

EP - 450

JO - Mayo Clinic Proceedings

JF - Mayo Clinic Proceedings

SN - 0025-6196

IS - 4

ER -