Beta cell nuclear musculoaponeurotic fibrosarcoma oncogene family A (MafA) is deficient in type 2 diabetes

A. E. Butler; R. P. Robertson; R. Hernandez; A. V. Matveyenko; T. Gurlo; P. C. Butler

doi:10.1007/s00125-012-2666-2

Beta cell nuclear musculoaponeurotic fibrosarcoma oncogene family A (MafA) is deficient in type 2 diabetes

A. E. Butler, R. P. Robertson, R. Hernandez, A. V. Matveyenko, T. Gurlo, P. C. Butler

Physiology & Biomedical Engineering

Research output: Contribution to journal › Article

33 Scopus citations

Abstract

Aims/hypothesis The beta cell transcriptional factor musculoaponeurotic fibrosarcoma oncogene family A (MafA) regulates genes important for beta cell function. Loss of nuclear MafA has been implicated in beta cell dysfunction in animal models of type 2 diabetes. We sought to establish if nuclear MafA is less abundant in beta cell nuclei in humans with type 2 diabetes. Methods Pancreas obtained at surgery from five nondiabetic individuals and six individuals with type 2 diabetes was immunostained for insulin, glucagon and MafA. Results Beta cell nuclear MafA was markedly decreased in type 2 diabetes (1.6±1.2% vs 46.3±8.3%, p<0.001). Conclusions/interpretation Beta cell nuclear MafA is markedly decreased in humans with type 2 diabetes, which may contribute to impaired beta cell dysfunction.

Original language	English (US)
Pages (from-to)	2985-2988
Number of pages	4
Journal	Diabetologia
Volume	55
Issue number	11
DOIs	https://doi.org/10.1007/s00125-012-2666-2
State	Published - Nov 2012

Keywords

Beta cell
Glucotoxicity
MafA

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism

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10.1007/s00125-012-2666-2

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Butler, A. E., Robertson, R. P., Hernandez, R., Matveyenko, A. V., Gurlo, T., & Butler, P. C. (2012). Beta cell nuclear musculoaponeurotic fibrosarcoma oncogene family A (MafA) is deficient in type 2 diabetes. Diabetologia, 55(11), 2985-2988. https://doi.org/10.1007/s00125-012-2666-2

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abstract = "Aims/hypothesis The beta cell transcriptional factor musculoaponeurotic fibrosarcoma oncogene family A (MafA) regulates genes important for beta cell function. Loss of nuclear MafA has been implicated in beta cell dysfunction in animal models of type 2 diabetes. We sought to establish if nuclear MafA is less abundant in beta cell nuclei in humans with type 2 diabetes. Methods Pancreas obtained at surgery from five nondiabetic individuals and six individuals with type 2 diabetes was immunostained for insulin, glucagon and MafA. Results Beta cell nuclear MafA was markedly decreased in type 2 diabetes (1.6±1.2% vs 46.3±8.3%, p<0.001). Conclusions/interpretation Beta cell nuclear MafA is markedly decreased in humans with type 2 diabetes, which may contribute to impaired beta cell dysfunction.",

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AU - Hernandez, R.

AU - Matveyenko, A. V.

AU - Gurlo, T.

AU - Butler, P. C.

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