Abstract
Aims/hypothesis The beta cell transcriptional factor musculoaponeurotic fibrosarcoma oncogene family A (MafA) regulates genes important for beta cell function. Loss of nuclear MafA has been implicated in beta cell dysfunction in animal models of type 2 diabetes. We sought to establish if nuclear MafA is less abundant in beta cell nuclei in humans with type 2 diabetes. Methods Pancreas obtained at surgery from five nondiabetic individuals and six individuals with type 2 diabetes was immunostained for insulin, glucagon and MafA. Results Beta cell nuclear MafA was markedly decreased in type 2 diabetes (1.6±1.2% vs 46.3±8.3%, p<0.001). Conclusions/interpretation Beta cell nuclear MafA is markedly decreased in humans with type 2 diabetes, which may contribute to impaired beta cell dysfunction.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2985-2988 |
| Number of pages | 4 |
| Journal | Diabetologia |
| Volume | 55 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 2012 |
| Externally published | Yes |
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Keywords
- Beta cell
- Glucotoxicity
- MafA
ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
Cite this
Beta cell nuclear musculoaponeurotic fibrosarcoma oncogene family A (MafA) is deficient in type 2 diabetes. / Butler, A. E.; Robertson, R. P.; Hernandez, R.; Matveyenko, Aleksey V; Gurlo, T.; Butler, P. C.
In: Diabetologia, Vol. 55, No. 11, 11.2012, p. 2985-2988.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Beta cell nuclear musculoaponeurotic fibrosarcoma oncogene family A (MafA) is deficient in type 2 diabetes
AU - Butler, A. E.
AU - Robertson, R. P.
AU - Hernandez, R.
AU - Matveyenko, Aleksey V
AU - Gurlo, T.
AU - Butler, P. C.
PY - 2012/11
Y1 - 2012/11
N2 - Aims/hypothesis The beta cell transcriptional factor musculoaponeurotic fibrosarcoma oncogene family A (MafA) regulates genes important for beta cell function. Loss of nuclear MafA has been implicated in beta cell dysfunction in animal models of type 2 diabetes. We sought to establish if nuclear MafA is less abundant in beta cell nuclei in humans with type 2 diabetes. Methods Pancreas obtained at surgery from five nondiabetic individuals and six individuals with type 2 diabetes was immunostained for insulin, glucagon and MafA. Results Beta cell nuclear MafA was markedly decreased in type 2 diabetes (1.6±1.2% vs 46.3±8.3%, p<0.001). Conclusions/interpretation Beta cell nuclear MafA is markedly decreased in humans with type 2 diabetes, which may contribute to impaired beta cell dysfunction.
AB - Aims/hypothesis The beta cell transcriptional factor musculoaponeurotic fibrosarcoma oncogene family A (MafA) regulates genes important for beta cell function. Loss of nuclear MafA has been implicated in beta cell dysfunction in animal models of type 2 diabetes. We sought to establish if nuclear MafA is less abundant in beta cell nuclei in humans with type 2 diabetes. Methods Pancreas obtained at surgery from five nondiabetic individuals and six individuals with type 2 diabetes was immunostained for insulin, glucagon and MafA. Results Beta cell nuclear MafA was markedly decreased in type 2 diabetes (1.6±1.2% vs 46.3±8.3%, p<0.001). Conclusions/interpretation Beta cell nuclear MafA is markedly decreased in humans with type 2 diabetes, which may contribute to impaired beta cell dysfunction.
KW - Beta cell
KW - Glucotoxicity
KW - MafA
UR - http://www.scopus.com/inward/record.url?scp=84867578003&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84867578003&partnerID=8YFLogxK
U2 - 10.1007/s00125-012-2666-2
DO - 10.1007/s00125-012-2666-2
M3 - Article
C2 - 22847061
AN - SCOPUS:84867578003
VL - 55
SP - 2985
EP - 2988
JO - Diabetologia
JF - Diabetologia
SN - 0012-186X
IS - 11
ER -