Beta-catenin mutations do not contribute to cardiac fibroma pathogenesis

Hua Wang, Dylan V. Miller, Huamin Wang, Michael E. Fealey, Henry D. Tazelaar

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Cardiac fibromas are the 2nd most common benign cardiac tumor occurring in children and bear a striking morphologic resemblance to soft tissue or desmoid fibromatosis. Since activating mutations in beta-catenin are common in desmoid fibromatosis as well as other spindle cell proliferations, the aim of our study was to determine if such mutations could be identified in cardiac fibroma. Nine cardiac fibromas from patients with surgical resection were examined for beta-catenin mutations by immunoperoxidase staining for beta-catenin protein and DNA sequencing of a region in exon 3 of the beta-catenin gene, where relatively conserved mutations have been described in desmoid fibromatosis. The mean age of the patients was 7.6 years (range: 10 weeks to 27 years), and 6 of the patients were male. No nuclear staining for beta-catenin was seen in the fibroma cells by immunoperoxidase methods. The beta-catenin exon 3 sequence data showed no mutations in any of the 9 rumors. We conclude that despite their morphologic similarity, cardiac fibroma and desmoid fibromatosis do not share this common molecular pathway of neoplastic growth.

Original languageEnglish (US)
Pages (from-to)291-294
Number of pages4
JournalPediatric and Developmental Pathology
Volume11
Issue number4
DOIs
StatePublished - Jul 2008

Fingerprint

Fibroma
beta Catenin
Mutation
Aggressive Fibromatosis
Exons
Staining and Labeling
Catenins
Heart Neoplasms
Protein Sequence Analysis
DNA Sequence Analysis
Cell Proliferation

Keywords

  • Beta-catenin
  • Cardiac neoplasms
  • Fibroma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine

Cite this

Beta-catenin mutations do not contribute to cardiac fibroma pathogenesis. / Wang, Hua; Miller, Dylan V.; Wang, Huamin; Fealey, Michael E.; Tazelaar, Henry D.

In: Pediatric and Developmental Pathology, Vol. 11, No. 4, 07.2008, p. 291-294.

Research output: Contribution to journalArticle

Wang, H, Miller, DV, Wang, H, Fealey, ME & Tazelaar, HD 2008, 'Beta-catenin mutations do not contribute to cardiac fibroma pathogenesis', Pediatric and Developmental Pathology, vol. 11, no. 4, pp. 291-294. https://doi.org/10.2350/07-08-0330.1
Wang, Hua ; Miller, Dylan V. ; Wang, Huamin ; Fealey, Michael E. ; Tazelaar, Henry D. / Beta-catenin mutations do not contribute to cardiac fibroma pathogenesis. In: Pediatric and Developmental Pathology. 2008 ; Vol. 11, No. 4. pp. 291-294.
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