TY - JOUR
T1 - Beta-amyloid deposition and paired helical filament formation
T2 - Which histopathological feature is more significant in Alzheimer's disease?
AU - Dickson, Dennis W.
AU - Yen, Shu Hui C.
PY - 1989
Y1 - 1989
N2 - Clinicopathological, biochemical, immunochemical and molecular biological studies of beta amyloid and neurofibrillary changes have been recently described by this and other laboratories. Although amyloid deposition is present in every AD brain, it is also present, sometimes in great quantities, in nondemented individuals. On the other hand, paired helical filament formation in perikarya (neurofibrillary tangles) and the neuropil of the cerebrum appears to be the histopathological feature that is most characteristic of AD.
AB - Clinicopathological, biochemical, immunochemical and molecular biological studies of beta amyloid and neurofibrillary changes have been recently described by this and other laboratories. Although amyloid deposition is present in every AD brain, it is also present, sometimes in great quantities, in nondemented individuals. On the other hand, paired helical filament formation in perikarya (neurofibrillary tangles) and the neuropil of the cerebrum appears to be the histopathological feature that is most characteristic of AD.
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U2 - 10.1016/0197-4580(89)90075-4
DO - 10.1016/0197-4580(89)90075-4
M3 - Article
C2 - 2682317
AN - SCOPUS:0024350203
SN - 0197-4580
VL - 10
SP - 402
EP - 404
JO - Neurobiology of aging
JF - Neurobiology of aging
IS - 5
ER -