Beta-amyloid deposition and paired helical filament formation: Which histopathological feature is more significant in Alzheimer's disease?

Dennis W Dickson; Shu Hui C Yen

doi:10.1016/0197-4580(89)90075-4

Beta-amyloid deposition and paired helical filament formation: Which histopathological feature is more significant in Alzheimer's disease?

Dennis W Dickson, Shu Hui C Yen

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Clinicopathological, biochemical, immunochemical and molecular biological studies of beta amyloid and neurofibrillary changes have been recently described by this and other laboratories. Although amyloid deposition is present in every AD brain, it is also present, sometimes in great quantities, in nondemented individuals. On the other hand, paired helical filament formation in perikarya (neurofibrillary tangles) and the neuropil of the cerebrum appears to be the histopathological feature that is most characteristic of AD.

Original language	English (US)
Pages (from-to)	402-404
Number of pages	3
Journal	Neurobiology of Aging
Volume	10
Issue number	5
DOIs	https://doi.org/10.1016/0197-4580(89)90075-4
State	Published - 1989
Externally published	Yes

ASJC Scopus subject areas

Clinical Neurology
Biological Psychiatry
Developmental Neuroscience
Neurology
Psychology(all)

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title = "Beta-amyloid deposition and paired helical filament formation: Which histopathological feature is more significant in Alzheimer's disease?",

abstract = "Clinicopathological, biochemical, immunochemical and molecular biological studies of beta amyloid and neurofibrillary changes have been recently described by this and other laboratories. Although amyloid deposition is present in every AD brain, it is also present, sometimes in great quantities, in nondemented individuals. On the other hand, paired helical filament formation in perikarya (neurofibrillary tangles) and the neuropil of the cerebrum appears to be the histopathological feature that is most characteristic of AD.",

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AU - Yen, Shu Hui C

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AB - Clinicopathological, biochemical, immunochemical and molecular biological studies of beta amyloid and neurofibrillary changes have been recently described by this and other laboratories. Although amyloid deposition is present in every AD brain, it is also present, sometimes in great quantities, in nondemented individuals. On the other hand, paired helical filament formation in perikarya (neurofibrillary tangles) and the neuropil of the cerebrum appears to be the histopathological feature that is most characteristic of AD.

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