Benign versus malignant Parkinson disease: the unexpected silver lining of motor complications

Aristide Merola, Alberto Romagnolo, Alok K. Dwivedi, Alessandro Padovani, Daniela Berg, Pedro J. Garcia-Ruiz, Margherita Fabbri, Carlo Alberto Artusi, Maurizio Zibetti, Leonardo Lopiano, Andrea Pilotto, Sonia Bonacina, Francesca Morgante, Kirsten Zeuner, Christopher Griewing, Eva Schaeffer, Federico Rodriguez-Porcel, Marcelo Kauffman, Pierpaolo Turcano, Lais M. de OliveiraGiovanni Palermo, Emily Shanks, Francesca Del Sorbo, Salvatore Bonvegna, Rodolfo Savica, Renato P. Munhoz, Roberto Ceravolo, Roberto Cilia, Alberto J. Espay

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Objective: We sought to evaluate demographic, clinical, and habits/occupational variables between phenotypic extremes in Parkinson’s disease (PD). Methods: Databases from nine movement disorders centers across seven countries were retrospectively searched for subjects meeting criteria for very slowly progressive, benign, PD (bPD) and rapidly progressive, malignant, PD (mPD). bPD was defined as Hoehn and Yahr (H&Y) stage ≤ 3, normal cognitive function, and Schwab and England (S&E) score ≥ 70 after ≥ 20 years of PD (≥ 10 years if older than 60 at PD onset); mPD as H&Y > 3, S&E score < 70, and cognitive impairment within 10 years from PD onset. We performed between-group analysis of demographic, habits/occupational, and clinical features at baseline and follow-up and unsupervised data-driven analysis of the clinical homogeneity of bPD and mPD. Results: At onset, bPD subjects (n = 210) were younger, had a single limb affected, lower severity and greater asymmetry of symptoms, and lower prevalence of depression than mPD (n = 155). bPD was associated with active smoking and physical activity, mPD with agricultural occupation. At follow-up, mPD showed higher prevalence of depression, hallucinations, dysautonomia, and REM behaviour disorder. Interestingly, the odds of mPD were significantly reduced by the presence of dyskinesia and wearing-off. Data-driven analysis confirmed the independent clustering of bPD and mPD, with age at onset emerging as a critical discriminant between the two groups (< 46-year-old vs. > 68-year-old). Conclusions: Phenotypic PD extremes showed distinct demographic, clinical, and habits/occupational factors. Motor complications may be conceived as markers of therapeutic success given their attenuating effects on the odds of mPD.

Original languageEnglish (US)
Pages (from-to)2949-2960
Number of pages12
JournalJournal of Neurology
Volume267
Issue number10
DOIs
StatePublished - Oct 1 2020

Keywords

  • Aging
  • Benign
  • Epidemiology
  • Malignant
  • Motor complications
  • Parkinson

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Merola, A., Romagnolo, A., Dwivedi, A. K., Padovani, A., Berg, D., Garcia-Ruiz, P. J., Fabbri, M., Artusi, C. A., Zibetti, M., Lopiano, L., Pilotto, A., Bonacina, S., Morgante, F., Zeuner, K., Griewing, C., Schaeffer, E., Rodriguez-Porcel, F., Kauffman, M., Turcano, P., ... Espay, A. J. (2020). Benign versus malignant Parkinson disease: the unexpected silver lining of motor complications. Journal of Neurology, 267(10), 2949-2960. https://doi.org/10.1007/s00415-020-09954-6