Benign fibrous dysplasia on [11C]choline PET

A potential mimicker of disease in patients with biochemical recurrence of prostate cancer

Chris N. Gu, Christopher H. Hunt, Vance T Lehman, Geoffrey B. Johnson, Felix E. Diehn, Kara M. Schwartz, Laurence J. Eckel

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We present the case of a 74-year-old male with biochemical recurrence of prostate cancer who underwent [11C]choline PET/CT. The PET/CT demonstrated an intense focus of uptake within the skull base that was initially felt to potentially represent metastatic disease. Subsequent evaluation with MRI and dedicated thin-section CT revealed this area to be benign fibrous dysplasia of the bone. The focal uptake on PET/CT with [11C]choline in benign fibrous dysplasia represents a potential mimicker of metastatic disease. Due to recognizing this benign process, our patient was able to avoid systemic treatment and/or focal radiation and was treated with cryotherapy for biopsy-proven local recurrence within the prostate bed. While benign fibrous dysplasia can demonstrate increased radiotracer uptake on other modalities (i.e., bone scintigraphy, FDG PET/CT), its appearance on [11C]choline PET/ CT has been largely overlooked in the literature. With the increasing use of [11C]choline PET/CT for biochemical recurrent prostate cancer evaluation, it is important to understand this potential mimicker of disease.

Original languageEnglish (US)
Pages (from-to)599-602
Number of pages4
JournalAnnals of Nuclear Medicine
Volume26
Issue number7
DOIs
StatePublished - Aug 2012

Fingerprint

Choline
Prostatic Neoplasms
Recurrence
Fibrous Dysplasia of Bone
Cryotherapy
Skull Base
Radionuclide Imaging
Prostate
Radiation
Biopsy
Bone and Bones
Therapeutics

Keywords

  • [C]choline
  • Fibrous dysplasia
  • PET/CT
  • Prostate cancer

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Benign fibrous dysplasia on [11C]choline PET : A potential mimicker of disease in patients with biochemical recurrence of prostate cancer. / Gu, Chris N.; Hunt, Christopher H.; Lehman, Vance T; Johnson, Geoffrey B.; Diehn, Felix E.; Schwartz, Kara M.; Eckel, Laurence J.

In: Annals of Nuclear Medicine, Vol. 26, No. 7, 08.2012, p. 599-602.

Research output: Contribution to journalArticle

Gu, Chris N. ; Hunt, Christopher H. ; Lehman, Vance T ; Johnson, Geoffrey B. ; Diehn, Felix E. ; Schwartz, Kara M. ; Eckel, Laurence J. / Benign fibrous dysplasia on [11C]choline PET : A potential mimicker of disease in patients with biochemical recurrence of prostate cancer. In: Annals of Nuclear Medicine. 2012 ; Vol. 26, No. 7. pp. 599-602.
@article{1b405c63f2fa4c27aa7f389b7edd3490,
title = "Benign fibrous dysplasia on [11C]choline PET: A potential mimicker of disease in patients with biochemical recurrence of prostate cancer",
abstract = "We present the case of a 74-year-old male with biochemical recurrence of prostate cancer who underwent [11C]choline PET/CT. The PET/CT demonstrated an intense focus of uptake within the skull base that was initially felt to potentially represent metastatic disease. Subsequent evaluation with MRI and dedicated thin-section CT revealed this area to be benign fibrous dysplasia of the bone. The focal uptake on PET/CT with [11C]choline in benign fibrous dysplasia represents a potential mimicker of metastatic disease. Due to recognizing this benign process, our patient was able to avoid systemic treatment and/or focal radiation and was treated with cryotherapy for biopsy-proven local recurrence within the prostate bed. While benign fibrous dysplasia can demonstrate increased radiotracer uptake on other modalities (i.e., bone scintigraphy, FDG PET/CT), its appearance on [11C]choline PET/ CT has been largely overlooked in the literature. With the increasing use of [11C]choline PET/CT for biochemical recurrent prostate cancer evaluation, it is important to understand this potential mimicker of disease.",
keywords = "[C]choline, Fibrous dysplasia, PET/CT, Prostate cancer",
author = "Gu, {Chris N.} and Hunt, {Christopher H.} and Lehman, {Vance T} and Johnson, {Geoffrey B.} and Diehn, {Felix E.} and Schwartz, {Kara M.} and Eckel, {Laurence J.}",
year = "2012",
month = "8",
doi = "10.1007/s12149-012-0610-7",
language = "English (US)",
volume = "26",
pages = "599--602",
journal = "Annals of Nuclear Medicine",
issn = "0914-7187",
publisher = "Springer Japan",
number = "7",

}

TY - JOUR

T1 - Benign fibrous dysplasia on [11C]choline PET

T2 - A potential mimicker of disease in patients with biochemical recurrence of prostate cancer

AU - Gu, Chris N.

AU - Hunt, Christopher H.

AU - Lehman, Vance T

AU - Johnson, Geoffrey B.

AU - Diehn, Felix E.

AU - Schwartz, Kara M.

AU - Eckel, Laurence J.

PY - 2012/8

Y1 - 2012/8

N2 - We present the case of a 74-year-old male with biochemical recurrence of prostate cancer who underwent [11C]choline PET/CT. The PET/CT demonstrated an intense focus of uptake within the skull base that was initially felt to potentially represent metastatic disease. Subsequent evaluation with MRI and dedicated thin-section CT revealed this area to be benign fibrous dysplasia of the bone. The focal uptake on PET/CT with [11C]choline in benign fibrous dysplasia represents a potential mimicker of metastatic disease. Due to recognizing this benign process, our patient was able to avoid systemic treatment and/or focal radiation and was treated with cryotherapy for biopsy-proven local recurrence within the prostate bed. While benign fibrous dysplasia can demonstrate increased radiotracer uptake on other modalities (i.e., bone scintigraphy, FDG PET/CT), its appearance on [11C]choline PET/ CT has been largely overlooked in the literature. With the increasing use of [11C]choline PET/CT for biochemical recurrent prostate cancer evaluation, it is important to understand this potential mimicker of disease.

AB - We present the case of a 74-year-old male with biochemical recurrence of prostate cancer who underwent [11C]choline PET/CT. The PET/CT demonstrated an intense focus of uptake within the skull base that was initially felt to potentially represent metastatic disease. Subsequent evaluation with MRI and dedicated thin-section CT revealed this area to be benign fibrous dysplasia of the bone. The focal uptake on PET/CT with [11C]choline in benign fibrous dysplasia represents a potential mimicker of metastatic disease. Due to recognizing this benign process, our patient was able to avoid systemic treatment and/or focal radiation and was treated with cryotherapy for biopsy-proven local recurrence within the prostate bed. While benign fibrous dysplasia can demonstrate increased radiotracer uptake on other modalities (i.e., bone scintigraphy, FDG PET/CT), its appearance on [11C]choline PET/ CT has been largely overlooked in the literature. With the increasing use of [11C]choline PET/CT for biochemical recurrent prostate cancer evaluation, it is important to understand this potential mimicker of disease.

KW - [C]choline

KW - Fibrous dysplasia

KW - PET/CT

KW - Prostate cancer

UR - http://www.scopus.com/inward/record.url?scp=84866730366&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84866730366&partnerID=8YFLogxK

U2 - 10.1007/s12149-012-0610-7

DO - 10.1007/s12149-012-0610-7

M3 - Article

VL - 26

SP - 599

EP - 602

JO - Annals of Nuclear Medicine

JF - Annals of Nuclear Medicine

SN - 0914-7187

IS - 7

ER -