Benefits and Risks of Nonsteroidal Antiinflammatory Drugs in Steroid-Resistant Nephrotic Syndrome

Jorge A. Velosa, Vicente E. Torres

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

In this paper we discuss the effects of nonsteroidal antiinflammatory drugs on proteinuria and the specific risks of these drugs in patients with nephrotic syndrome. We summarize the results of a prospective uncontrolled trial of meclofenamate in severe steroid-resistant nephrotic syndrome secondary to focal glomerular sclerosis and idiopathic membranous nephropathy. This study examined the effect of meclofenamate on proteinuria, serum albumin levels, serum cholesterol, serum triglycerides, renal function, BP, liver function tests, and hemotologic values. We also sought and evaluated adverse reactions due to this medication. We offer some suggestions for selective use and careful supervision of NSAIDs in the nephrotic syndrome.

Original languageEnglish (US)
Pages (from-to)345-350
Number of pages6
JournalAmerican Journal of Kidney Diseases
Volume8
Issue number5
DOIs
StatePublished - Jan 1 1986

Keywords

  • Nonsteroidal antiinflammatory drugs
  • nephrotic syndrome
  • proteinuria
  • renal function
  • side effects

ASJC Scopus subject areas

  • Nephrology

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