TY - JOUR
T1 - Beneficial effects of polyphenol-rich olive oil in patients with early atherosclerosis
AU - Widmer, R. J.
AU - Freund, M. A.
AU - Flammer, A. J.
AU - Sexton, J.
AU - Lennon, R.
AU - Romani, A.
AU - Mulinacci, N.
AU - Vinceri, F. F.
AU - Lerman, L. O.
AU - Lerman, A.
N1 - Funding Information:
Acknowledgments This study was partly supported by Olivi Agri Team Srl, Grosetto, Italy, and the University of Florence. However, the study was investigator initiated and investigator driven. The clinical trial was conducted using Olive Oil and EGCG from Olivi Agri Company. This work was also partly supported by NIH grant #HL085307. AJF received a scholarship from the Walter and Gertrud Siegenthaler Foundation, Zurich, and is supported by a ‘‘Nac-hwuchsförderungskredit’’ of the young academics Support Committee of the University of Zurich, Switzerland, and the Swiss National Science Foundation (PASMP3_132551).
PY - 2013/4
Y1 - 2013/4
N2 - Purpose: Diets rich in plant-derived polyphenols such as olive oil (OO) and/or catechins such as epigallocatechin 3-gallate (EGCG) have been shown to reduce the incidence of cardiovascular diseases, potentially by improving endothelial function, an important surrogate for atherosclerosis. The possible augmentation of endothelial function with the combined efforts of OO and EGCG is intriguing, yet unknown. Methods: Eighty-two patients with early atherosclerosis (presence of endothelial dysfunction) were enrolled in this double-blind, randomized trial with 52 completing the study. The aim of the study was to compare the effect of a daily intake of 30 ml simple OO, with 30 ml of EGCG-supplemented OO, on endothelial function as well as on inflammation and oxidative stress after a period of 4 months. Endothelial function was assessed noninvasively via peripheral arterial tonometry (Endo-PAT®). Results: After 4 months, when OO and EGCG-supplemented OO groups were combined, OO significantly improved endothelial function (RHI, 1.59 ± 0.25-1.75 ± 0.45; p < 0.05). However, there were no significant differences in results between the two olive oil groups. Interestingly, with OO supplementation there was a significant reduction in inflammatory parameters: sICAM (196 to 183 ng/mL, p = < 0.001); white blood cells (WBCs) (6.0 × 10 9/L-5.8 × 109/L, p < 0.05); monocytes (0.48 × 109/L to 0.44 × 109/L, p = 0.05); lymphocytes (1.85 × 109/L to 1.6 × 109/L, p = 0.01); and platelets (242-229 × 109/L, p = 0.047). Conclusions: Improvement in endothelial dysfunction in patients with early atherosclerosis in association with significant reduction in leukocytes may suggest an important role of early cellular inflammatory mediators on endothelial function. The current study supports one potential mechanism for the role of olive oil, independent of EGCG, modestly supplemented to a healthy cardiovascular diet.
AB - Purpose: Diets rich in plant-derived polyphenols such as olive oil (OO) and/or catechins such as epigallocatechin 3-gallate (EGCG) have been shown to reduce the incidence of cardiovascular diseases, potentially by improving endothelial function, an important surrogate for atherosclerosis. The possible augmentation of endothelial function with the combined efforts of OO and EGCG is intriguing, yet unknown. Methods: Eighty-two patients with early atherosclerosis (presence of endothelial dysfunction) were enrolled in this double-blind, randomized trial with 52 completing the study. The aim of the study was to compare the effect of a daily intake of 30 ml simple OO, with 30 ml of EGCG-supplemented OO, on endothelial function as well as on inflammation and oxidative stress after a period of 4 months. Endothelial function was assessed noninvasively via peripheral arterial tonometry (Endo-PAT®). Results: After 4 months, when OO and EGCG-supplemented OO groups were combined, OO significantly improved endothelial function (RHI, 1.59 ± 0.25-1.75 ± 0.45; p < 0.05). However, there were no significant differences in results between the two olive oil groups. Interestingly, with OO supplementation there was a significant reduction in inflammatory parameters: sICAM (196 to 183 ng/mL, p = < 0.001); white blood cells (WBCs) (6.0 × 10 9/L-5.8 × 109/L, p < 0.05); monocytes (0.48 × 109/L to 0.44 × 109/L, p = 0.05); lymphocytes (1.85 × 109/L to 1.6 × 109/L, p = 0.01); and platelets (242-229 × 109/L, p = 0.047). Conclusions: Improvement in endothelial dysfunction in patients with early atherosclerosis in association with significant reduction in leukocytes may suggest an important role of early cellular inflammatory mediators on endothelial function. The current study supports one potential mechanism for the role of olive oil, independent of EGCG, modestly supplemented to a healthy cardiovascular diet.
KW - Atherosclerosis
KW - Endothelial function
KW - Inflammation
KW - Olive oil
KW - Oxidative stress
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U2 - 10.1007/s00394-012-0433-2
DO - 10.1007/s00394-012-0433-2
M3 - Article
C2 - 22872323
AN - SCOPUS:84879550271
SN - 1436-6207
VL - 52
SP - 1223
EP - 1231
JO - European Journal of Nutrition
JF - European Journal of Nutrition
IS - 3
ER -