Behçet's syndrome and focal segmental glomerulosclerosis with nephrotic syndrome - Successful treatment with etanercept

Deanne Leonard, Cherise Cortese, Hani M. Wadei, Ivan Porter, Nabeel Aslam

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Behçet's syndrome (BS) often presents with aphthous and genital ulcers, uveitis, and erythema nodosum. Renal involvement has been reported with most cases presenting with renal amyloidosis, IgA nephropathy, or crescentic glomerulonephritis. We describe a case of a 49-yearold woman with relapsing BS symptoms coinciding with new-onset development of nephrotic syndrome. Renal biopsy showed focal segmental glomerulosclerosis (FSGS) that was treated with prednisone and etanercept for BS therapy. Both proteinuria and BS symptoms responded to treatment with complete remission. To our knowledge, our report is the first to show evidence of a possible connection between BS and FSGS and discusses the pathophysiologic mechanism that explains this link.

Original languageEnglish (US)
Pages (from-to)371-375
Number of pages5
JournalClinical Nephrology
Volume89
Issue number5
DOIs
StatePublished - May 1 2018

Keywords

  • Behçet's syndrome
  • Etanercept
  • FSGS
  • Nephrotic syndrome

ASJC Scopus subject areas

  • Nephrology

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