Behçet's disease as a causative factor of cerebral venous sinus thrombosis: Subgroup analysis of data from the VENOST study

Derya Uluduz, Ipek Midi, Taskin Duman, Sena Colakoglu, Ahmet Tüfekci, Mustafa Bakar, Bijen Nazliel, Nida Tascilar, Baki Goksan, Mehmet Ali Sungur, Hasan Huseyin Kozak, Serkan Demir, Cemile Handan Misirli, Hayriye Kucukoglu, Nilgun Cinar, Fusun Mayda Domac, Serefnur Ozturk, Vildan Yayla, Ali Yavuz Karahan, Nazire AfsarEylem Ozaydin Goksu, Necdet Mengulluoglu, Emrah Aytac, Nilufer Yesilot, Birsen Ince, Ozgur Osman Yalin, Serdar Oruc, Seden Demirci, Mehmet Guney Senol, Arda Yilmaz, Mustafa Gokce, Özge Yilmaz Kusbeci, Gulnur Uzuner, Hale Zeynep Batur Caglayan, Mustafa Acikgoz, Burcu Zeydan, Fatih Ozdag, Sevim Baybas, Hakan Ekmekci, Murat Cabalar, Mehmet Yaman, Vedat Ali Yurekli, Hakan Tekeli, Hamit Genc, Uygar Utku, Firdevs Ezgi Ucan Tokuc, Nevzat Uzuner, Hesna Bektas, Yuksel Kablan, Basak K. Goksel, Aysel Milanlioglu, Dilek Necioglu Orken, Ufuk Aluclu

Research output: Contribution to journalArticlepeer-review

Abstract

Objective. This study was performed to determine the rate of cerebral venous sinus thrombosis (CVST) among cases of Behç et's disease (BD) included in a multicentre study of cerebral venous sinus thrombosis (VENOST). Methods. VENOST was a retrospective and prospective national multicentre observational study that included 1144 patients with CVST. The patients were classified according to aetiologic factors, time of CVST symptom onset, sinus involvement, treatment approach and prognosis. Results. BD was shown to be a causative factor of CVST in 108 (9.4%) of 1144 patients. The mean age of patients in the BD group was 35.27 years and 68.5% were men, whereas in the non-BD CVST group, the mean age was 40.57 years and 28.3% were men (P < 0.001). Among the aetiologic factors for patients aged 1836 years, BD was predominant for men, and puerperium was predominant for women. The onset of symptoms in the BD group was consistent with the subacute form. The transverse sinuses were the most common sites of thrombosis, followed by the superior sagittal sinuses. The most common symptom was headache (96.2%), followed by visual field defects (38%). Conclusions. BD was found in 9.4% of patients in our VENOST series. Patients with BD were younger and showed a male predominance. The functional outcome of CVST in patients with BD was good; only 12% of patients presenting with cranial nerve involvement and altered consciousness at the beginning had a poor outcome (modified Rankin Score 52).

Original languageEnglish (US)
Pages (from-to)600-608
Number of pages9
JournalRheumatology (United Kingdom)
Volume58
Issue number4
DOIs
StatePublished - Apr 1 2019

Keywords

  • Behcet's disease
  • cerebral venous sinus thrombosis
  • outcome
  • subgroup analysis
  • VENOST study

ASJC Scopus subject areas

  • Rheumatology
  • Pharmacology (medical)

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