Basics of Skin Testing and Drug Challenges

Miguel Park, Sara M. May

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In addition to the clinical history, skin testing and/or drug challenges are an important component in the evaluation and management of adverse drug reactions. Although skin testing to drugs plays an important role in the evaluation and management of adverse drug reactions, the diagnostic value of skin testing to various medications is dependent on the drug of interest. The best studied skin testing to a medication is penicillin, which has been shown to have a >90% negative predictive value for IgE-mediated adverse drug reactions. Drug challenges to the medication are the gold standard in determining the culprit medication and/or to determine the tolerance of medications in the evaluation and management of adverse drug reactions and have been shown to be safe when performed by a trained professional in the appropriate clinical situation. In this chapter, we describe and discuss the role of skin testing and/or drug challenges of various medications in the evaluation and management of adverse drug reactions.

Original languageEnglish (US)
Title of host publicationDrug Allergy Testing
PublisherElsevier Inc.
Pages73-84
Number of pages12
ISBN (Electronic)9780323497077
ISBN (Print)9780323485517
DOIs
StatePublished - Jul 28 2017

Fingerprint

Drug-Related Side Effects and Adverse Reactions
Skin
Pharmaceutical Preparations
Penicillins
Immunoglobulin E

Keywords

  • Adverse drug reactions
  • Drug challenge
  • IgE-mediated adverse drug reactions
  • Nonirritating concentration
  • Skin testing

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

Cite this

Park, M., & May, S. M. (2017). Basics of Skin Testing and Drug Challenges. In Drug Allergy Testing (pp. 73-84). Elsevier Inc.. https://doi.org/10.1016/B978-0-323-48551-7.00007-9

Basics of Skin Testing and Drug Challenges. / Park, Miguel; May, Sara M.

Drug Allergy Testing. Elsevier Inc., 2017. p. 73-84.

Research output: Chapter in Book/Report/Conference proceedingChapter

Park, M & May, SM 2017, Basics of Skin Testing and Drug Challenges. in Drug Allergy Testing. Elsevier Inc., pp. 73-84. https://doi.org/10.1016/B978-0-323-48551-7.00007-9
Park M, May SM. Basics of Skin Testing and Drug Challenges. In Drug Allergy Testing. Elsevier Inc. 2017. p. 73-84 https://doi.org/10.1016/B978-0-323-48551-7.00007-9
Park, Miguel ; May, Sara M. / Basics of Skin Testing and Drug Challenges. Drug Allergy Testing. Elsevier Inc., 2017. pp. 73-84
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