Basic principles of antineoplastic therapies

Tufia C Haddad, Douglas Yee

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Antineoplastic therapies can be classified as either cytotoxic systemic chemotherapy or targeted biological therapy. In many ways, cytotoxic chemotherapy is "targeted" at specific molecules that regulate progression through the cell cycle; however, these targets are generally not specific for tumor cells. Because systemic cytotoxic chemotherapy targets all rapidly dividing cells, it also attacks hair follicles, gastrointestinal mucosa, and hematopoietic cells thereby inducing the classical side effects of treatment such as alopecia, nausea, diarrhea, mucositis, and bone marrow suppression. The newer generation of targeted biological therapies is still administered systemically as traditional chemotherapy; however, these drugs are unique in that they are designed to target specific molecular components in tumor cell biology with the hope of minimizing cytotoxicity to noncancerous cells. In addition, they have toxicities specific to their mechanism of action. This chapter provides an overview of the biology of systemic therapy for breast cancer.

Original languageEnglish (US)
Title of host publicationBreast Surgical Techniques and Interdisciplinary Management
PublisherSpringer New York
Pages707-715
Number of pages9
ISBN (Print)9781441960757
DOIs
StatePublished - 2011
Externally publishedYes

Fingerprint

Antineoplastic Agents
Drug Therapy
Biological Therapy
Mucositis
Hair Follicle
Alopecia
Therapeutics
Nausea
Cell Biology
Diarrhea
Neoplasms
Cell Cycle
Mucous Membrane
Bone Marrow
Breast Neoplasms
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Haddad, T. C., & Yee, D. (2011). Basic principles of antineoplastic therapies. In Breast Surgical Techniques and Interdisciplinary Management (pp. 707-715). Springer New York. https://doi.org/10.1007/978-1-4419-6076-4_58

Basic principles of antineoplastic therapies. / Haddad, Tufia C; Yee, Douglas.

Breast Surgical Techniques and Interdisciplinary Management. Springer New York, 2011. p. 707-715.

Research output: Chapter in Book/Report/Conference proceedingChapter

Haddad, TC & Yee, D 2011, Basic principles of antineoplastic therapies. in Breast Surgical Techniques and Interdisciplinary Management. Springer New York, pp. 707-715. https://doi.org/10.1007/978-1-4419-6076-4_58
Haddad TC, Yee D. Basic principles of antineoplastic therapies. In Breast Surgical Techniques and Interdisciplinary Management. Springer New York. 2011. p. 707-715 https://doi.org/10.1007/978-1-4419-6076-4_58
Haddad, Tufia C ; Yee, Douglas. / Basic principles of antineoplastic therapies. Breast Surgical Techniques and Interdisciplinary Management. Springer New York, 2011. pp. 707-715
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