Basic fibroblast growth factor promotes in vivo cerebral angiogenesis in chronic forebrain ischemia

Mark K. Lyons; Robert E. Anderson; Fredric B. Meyer

doi:10.1016/0006-8993(91)90784-S

Basic fibroblast growth factor promotes in vivo cerebral angiogenesis in chronic forebrain ischemia

Mark K. Lyons, Robert E. Anderson, Fredric B. Meyer

Neurosurgery

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

This experiment was designed to determine if intraventricular administration of basic fibroblast growth factor (bFGF) could promote cerebral angiogenesis in a model of mild chronic forebrain ischemia. Wistar rats underwent bilateral carotid artery ligation. Animals received intraventricular injections of bFGF every 4 days for 28 days. Basic fibroblast growth factor caused a significant dose-dependent increase in capillary density compared to ischemic controls in all regions examined. These results support the hypothesis that chronic intraventricular administration of bFGF induces in vivo cerebral angiogenesis.

Original language	English (US)
Pages (from-to)	315-320
Number of pages	6
Journal	Brain Research
Volume	558
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(91)90784-S
State	Published - Sep 6 1991

Keywords

Angiogenesis
Basic fibroblast growth factor
Capillary
Ischemia
Rat

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(91)90784-S

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AB - This experiment was designed to determine if intraventricular administration of basic fibroblast growth factor (bFGF) could promote cerebral angiogenesis in a model of mild chronic forebrain ischemia. Wistar rats underwent bilateral carotid artery ligation. Animals received intraventricular injections of bFGF every 4 days for 28 days. Basic fibroblast growth factor caused a significant dose-dependent increase in capillary density compared to ischemic controls in all regions examined. These results support the hypothesis that chronic intraventricular administration of bFGF induces in vivo cerebral angiogenesis.

KW - Angiogenesis

KW - Basic fibroblast growth factor

KW - Capillary

KW - Ischemia

KW - Rat

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Basic fibroblast growth factor promotes in vivo cerebral angiogenesis in chronic forebrain ischemia

Abstract

Keywords

ASJC Scopus subject areas

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