Basic fibroblast growth factor promotes in vivo cerebral angiogenesis in chronic forebrain ischemia

Mark K. Lyons, Robert E. Anderson, Fredric B. Meyer

Research output: Contribution to journalArticle

65 Scopus citations

Abstract

This experiment was designed to determine if intraventricular administration of basic fibroblast growth factor (bFGF) could promote cerebral angiogenesis in a model of mild chronic forebrain ischemia. Wistar rats underwent bilateral carotid artery ligation. Animals received intraventricular injections of bFGF every 4 days for 28 days. Basic fibroblast growth factor caused a significant dose-dependent increase in capillary density compared to ischemic controls in all regions examined. These results support the hypothesis that chronic intraventricular administration of bFGF induces in vivo cerebral angiogenesis.

Original languageEnglish (US)
Pages (from-to)315-320
Number of pages6
JournalBrain Research
Volume558
Issue number2
DOIs
StatePublished - Sep 6 1991

Keywords

  • Angiogenesis
  • Basic fibroblast growth factor
  • Capillary
  • Ischemia
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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