Basic concepts in glioma immunology

Research output: Chapter in Book/Report/Conference proceedingChapter

33 Scopus citations

Abstract

Glioblasotmas are the most common primary central nervous system tumor and typically have a dismal prognosis. Immunotherapy has been a promising experimental treatment. Understanding brain tumor immunobiology is critical to designing glioblasotma immunotherapies. In this chapter, we review aspects of basic immunology and neuro-immunology. The antigenic underpinnings of brain tumor immunotherapy including glioma-associated and glioma-specific antigens are discussed. Finally, the molecular and cellular facets of glioma-mediated immunosuppression are outlined. The role of multiple cell types (glioma cells, glioma-infiltrating monocytes, regulatory T cells and myeloid derived suppressor cells) in mediating local and systemic immunosuppression in glioma patients is evaluated.

Original languageEnglish (US)
Title of host publicationGlioma
Subtitle of host publicationImmunotherapeutic Approaches
EditorsRyuya Yamanaka
Pages42-52
Number of pages11
DOIs
StatePublished - Jul 3 2012

Publication series

NameAdvances in Experimental Medicine and Biology
Volume746
ISSN (Print)0065-2598

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Parney, I. F. (2012). Basic concepts in glioma immunology. In R. Yamanaka (Ed.), Glioma: Immunotherapeutic Approaches (pp. 42-52). (Advances in Experimental Medicine and Biology; Vol. 746). https://doi.org/10.1007/978-1-4614-3146-6_4