@inbook{17b7cc98de684e69b96b39ea25117b85,
title = "Basic concepts in glioma immunology",
abstract = "Glioblasotmas are the most common primary central nervous system tumor and typically have a dismal prognosis. Immunotherapy has been a promising experimental treatment. Understanding brain tumor immunobiology is critical to designing glioblasotma immunotherapies. In this chapter, we review aspects of basic immunology and neuro-immunology. The antigenic underpinnings of brain tumor immunotherapy including glioma-associated and glioma-specific antigens are discussed. Finally, the molecular and cellular facets of glioma-mediated immunosuppression are outlined. The role of multiple cell types (glioma cells, glioma-infiltrating monocytes, regulatory T cells and myeloid derived suppressor cells) in mediating local and systemic immunosuppression in glioma patients is evaluated.",
author = "Parney, {Ian F.}",
year = "2012",
doi = "10.1007/978-1-4614-3146-6_4",
language = "English (US)",
isbn = "9781461431459",
series = "Advances in Experimental Medicine and Biology",
pages = "42--52",
editor = "Ryuya Yamanaka",
booktitle = "Glioma",
}