Baseline serum cholesterol is selectively associated with motor speed and not rates of cognitive decline: The Women's Health and Aging Study II

Michelle M Mielke, Qian Li Xue, Jing Zhou, Paulo H M Chaves, Linda P. Fried, Michelle C. Carlson

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background. Although several studies have investigated the association between cholesterol and dementia, few have examined cholesterol and decline across cognitive domains. We examined serum total and high-density lipoprotein (HDL) cholesterol, total-to-HDL ratio, and trajectories across cognitive domains. Methods. Participants were 436 community-residing women (70-79 years old) in the Women's Health and Aging Study II; they were screened to be physically high-functioning and cognitively intact at baseline. Cognition and other health-related variables were assessed at five intervals spanning 9 years. Cognitive assessments included Trail Making Test Parts A (TMT-A) and B (TMT-B), Hopkins Verbal Learning Test-Revised, Purdue Pegboard, and Mini-Mental State Examination (MMSE). The association between baseline levels of serum lipids and cognitive trajectories were evaluated using Generalized Estimating Equations (GEE). Covariates included age, education, race, vascular disease, serum creatinine, depression, and lipid-lowering medications. Results. In multivariate analyses, baseline higher total (p = .02) and HDL (p = .03) cholesterol were associated with better performance on the Purdue Pegboard. Using clinical cholesterol cutoffs, baseline serum total cholesterol levels .240 mg/dL were associated with the best performance (p = .02). Baseline lipids were not associated with any other cognitive tests; there were no Lipid 3 Time interactions. Conclusion. Higher baseline serum lipid levels predicted better performance over time on a measure of motor speed, but not memory or psychomotor or executive functioning in this population of elderly women. This association suggests that peripheral cholesterol levels, measured in late-life, may not be a good predictor of subsequent cognitive decline. Future research examining peripheral cholesterol over the life span and its relationship with cognition is needed.

Original languageEnglish (US)
Pages (from-to)619-624
Number of pages6
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume63
Issue number6
StatePublished - Jun 2008
Externally publishedYes

Fingerprint

Women's Health
Cholesterol
Serum
Lipids
HDL Lipoproteins
Cognition
Trail Making Test
Verbal Learning
Cognitive Dysfunction
Vascular Diseases
HDL Cholesterol
Dementia
Creatinine
Multivariate Analysis
Depression
Education
Health
Population

Keywords

  • Biological aging
  • Cholesterol
  • Cognition
  • Motor speed

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Cite this

Baseline serum cholesterol is selectively associated with motor speed and not rates of cognitive decline : The Women's Health and Aging Study II. / Mielke, Michelle M; Xue, Qian Li; Zhou, Jing; Chaves, Paulo H M; Fried, Linda P.; Carlson, Michelle C.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 63, No. 6, 06.2008, p. 619-624.

Research output: Contribution to journalArticle

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abstract = "Background. Although several studies have investigated the association between cholesterol and dementia, few have examined cholesterol and decline across cognitive domains. We examined serum total and high-density lipoprotein (HDL) cholesterol, total-to-HDL ratio, and trajectories across cognitive domains. Methods. Participants were 436 community-residing women (70-79 years old) in the Women's Health and Aging Study II; they were screened to be physically high-functioning and cognitively intact at baseline. Cognition and other health-related variables were assessed at five intervals spanning 9 years. Cognitive assessments included Trail Making Test Parts A (TMT-A) and B (TMT-B), Hopkins Verbal Learning Test-Revised, Purdue Pegboard, and Mini-Mental State Examination (MMSE). The association between baseline levels of serum lipids and cognitive trajectories were evaluated using Generalized Estimating Equations (GEE). Covariates included age, education, race, vascular disease, serum creatinine, depression, and lipid-lowering medications. Results. In multivariate analyses, baseline higher total (p = .02) and HDL (p = .03) cholesterol were associated with better performance on the Purdue Pegboard. Using clinical cholesterol cutoffs, baseline serum total cholesterol levels .240 mg/dL were associated with the best performance (p = .02). Baseline lipids were not associated with any other cognitive tests; there were no Lipid 3 Time interactions. Conclusion. Higher baseline serum lipid levels predicted better performance over time on a measure of motor speed, but not memory or psychomotor or executive functioning in this population of elderly women. This association suggests that peripheral cholesterol levels, measured in late-life, may not be a good predictor of subsequent cognitive decline. Future research examining peripheral cholesterol over the life span and its relationship with cognition is needed.",
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