Baseline renal function status limits patient eligibility to receive perioperative chemotherapy for invasive bladder cancer and is minimally affected by radical cystectomy

Daniel Canter, Rosalia Viterbo, Alexander Kutikov, Yu Ning Wong, Elizabeth Plimack, Fang Zhu, Megan Oblaczynski, Raffi Berberian, David Y T Chen, Richard E. Greenberg, Robert G. Uzzo, Stephen A. Boorjian

Research output: Contribution to journalArticle

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Abstract

Objectives: To evaluate the proportion of patients with muscle-invasive urothelial carcinoma (UC) who would be eligible to receive cisplatin-based chemotherapy before and after radical cystectomy based on renal function. Methods: We identified 194 consecutive patients who underwent cystectomy for cT2-T4 UC. Serum creatinine (SCr) immediately before and nadir SCr 1-3 months after surgery were used to calculate creatinine clearance (CrCl) and glomerular filtration rate (GFR). A cut-off CrCl < 60 mL/min or GFR < 60 mL/min/1.73 m2 was used to determine eligibility for chemotherapy. Results: Median patient age was 70.5 years (IQR 63.77) and median preoperative SCr was 1.05 mg/dL (0.9, 1.3). In total, 80/194 (41%) and 64/194 (33%) patients had inadequate renal function to receive chemotherapy before cystectomy based on CrCl and GFR, respectively. The frequency of inadequate baseline renal function increased significantly with patient age, from 12% of patients < 65 to 54% of patients >65 years of age (P < 0.0001). Surgery did not adversely affect the proportion of patients eligible to receive chemotherapy based on renal function, regardless of age. In fact, after controlling for gender, race, preoperative renal function, hydronephrosis, and choice of diversion, patients <65 years of age were found to have a 14% increase in CrCl (P = .01) and an 11% increase in GFR (P = .04) after cystectomy. Conclusions: Approximately 40% of patients who would be candidates for neoadjuvant chemotherapy could not receive cisplatin because of poor renal function. Surgery did not affect patients' eligibility to receive chemotherapy based on renal function status. Development of effective noncisplatin-based regimens is therefore necessary to optimize survival.

Original languageEnglish (US)
Pages (from-to)160-165
Number of pages6
JournalUrology
Volume77
Issue number1
DOIs
StatePublished - Jan 2011
Externally publishedYes

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Cystectomy
Urinary Bladder Neoplasms
Creatinine
Kidney
Drug Therapy
Glomerular Filtration Rate
Cisplatin
Carcinoma
Hydronephrosis
Serum
Muscles
Survival

ASJC Scopus subject areas

  • Urology

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Baseline renal function status limits patient eligibility to receive perioperative chemotherapy for invasive bladder cancer and is minimally affected by radical cystectomy. / Canter, Daniel; Viterbo, Rosalia; Kutikov, Alexander; Wong, Yu Ning; Plimack, Elizabeth; Zhu, Fang; Oblaczynski, Megan; Berberian, Raffi; Chen, David Y T; Greenberg, Richard E.; Uzzo, Robert G.; Boorjian, Stephen A.

In: Urology, Vol. 77, No. 1, 01.2011, p. 160-165.

Research output: Contribution to journalArticle

Canter, D, Viterbo, R, Kutikov, A, Wong, YN, Plimack, E, Zhu, F, Oblaczynski, M, Berberian, R, Chen, DYT, Greenberg, RE, Uzzo, RG & Boorjian, SA 2011, 'Baseline renal function status limits patient eligibility to receive perioperative chemotherapy for invasive bladder cancer and is minimally affected by radical cystectomy', Urology, vol. 77, no. 1, pp. 160-165. https://doi.org/10.1016/j.urology.2010.03.091
Canter, Daniel ; Viterbo, Rosalia ; Kutikov, Alexander ; Wong, Yu Ning ; Plimack, Elizabeth ; Zhu, Fang ; Oblaczynski, Megan ; Berberian, Raffi ; Chen, David Y T ; Greenberg, Richard E. ; Uzzo, Robert G. ; Boorjian, Stephen A. / Baseline renal function status limits patient eligibility to receive perioperative chemotherapy for invasive bladder cancer and is minimally affected by radical cystectomy. In: Urology. 2011 ; Vol. 77, No. 1. pp. 160-165.
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abstract = "Objectives: To evaluate the proportion of patients with muscle-invasive urothelial carcinoma (UC) who would be eligible to receive cisplatin-based chemotherapy before and after radical cystectomy based on renal function. Methods: We identified 194 consecutive patients who underwent cystectomy for cT2-T4 UC. Serum creatinine (SCr) immediately before and nadir SCr 1-3 months after surgery were used to calculate creatinine clearance (CrCl) and glomerular filtration rate (GFR). A cut-off CrCl < 60 mL/min or GFR < 60 mL/min/1.73 m2 was used to determine eligibility for chemotherapy. Results: Median patient age was 70.5 years (IQR 63.77) and median preoperative SCr was 1.05 mg/dL (0.9, 1.3). In total, 80/194 (41{\%}) and 64/194 (33{\%}) patients had inadequate renal function to receive chemotherapy before cystectomy based on CrCl and GFR, respectively. The frequency of inadequate baseline renal function increased significantly with patient age, from 12{\%} of patients < 65 to 54{\%} of patients >65 years of age (P < 0.0001). Surgery did not adversely affect the proportion of patients eligible to receive chemotherapy based on renal function, regardless of age. In fact, after controlling for gender, race, preoperative renal function, hydronephrosis, and choice of diversion, patients <65 years of age were found to have a 14{\%} increase in CrCl (P = .01) and an 11{\%} increase in GFR (P = .04) after cystectomy. Conclusions: Approximately 40{\%} of patients who would be candidates for neoadjuvant chemotherapy could not receive cisplatin because of poor renal function. Surgery did not affect patients' eligibility to receive chemotherapy based on renal function status. Development of effective noncisplatin-based regimens is therefore necessary to optimize survival.",
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T1 - Baseline renal function status limits patient eligibility to receive perioperative chemotherapy for invasive bladder cancer and is minimally affected by radical cystectomy

AU - Canter, Daniel

AU - Viterbo, Rosalia

AU - Kutikov, Alexander

AU - Wong, Yu Ning

AU - Plimack, Elizabeth

AU - Zhu, Fang

AU - Oblaczynski, Megan

AU - Berberian, Raffi

AU - Chen, David Y T

AU - Greenberg, Richard E.

AU - Uzzo, Robert G.

AU - Boorjian, Stephen A.

PY - 2011/1

Y1 - 2011/1

N2 - Objectives: To evaluate the proportion of patients with muscle-invasive urothelial carcinoma (UC) who would be eligible to receive cisplatin-based chemotherapy before and after radical cystectomy based on renal function. Methods: We identified 194 consecutive patients who underwent cystectomy for cT2-T4 UC. Serum creatinine (SCr) immediately before and nadir SCr 1-3 months after surgery were used to calculate creatinine clearance (CrCl) and glomerular filtration rate (GFR). A cut-off CrCl < 60 mL/min or GFR < 60 mL/min/1.73 m2 was used to determine eligibility for chemotherapy. Results: Median patient age was 70.5 years (IQR 63.77) and median preoperative SCr was 1.05 mg/dL (0.9, 1.3). In total, 80/194 (41%) and 64/194 (33%) patients had inadequate renal function to receive chemotherapy before cystectomy based on CrCl and GFR, respectively. The frequency of inadequate baseline renal function increased significantly with patient age, from 12% of patients < 65 to 54% of patients >65 years of age (P < 0.0001). Surgery did not adversely affect the proportion of patients eligible to receive chemotherapy based on renal function, regardless of age. In fact, after controlling for gender, race, preoperative renal function, hydronephrosis, and choice of diversion, patients <65 years of age were found to have a 14% increase in CrCl (P = .01) and an 11% increase in GFR (P = .04) after cystectomy. Conclusions: Approximately 40% of patients who would be candidates for neoadjuvant chemotherapy could not receive cisplatin because of poor renal function. Surgery did not affect patients' eligibility to receive chemotherapy based on renal function status. Development of effective noncisplatin-based regimens is therefore necessary to optimize survival.

AB - Objectives: To evaluate the proportion of patients with muscle-invasive urothelial carcinoma (UC) who would be eligible to receive cisplatin-based chemotherapy before and after radical cystectomy based on renal function. Methods: We identified 194 consecutive patients who underwent cystectomy for cT2-T4 UC. Serum creatinine (SCr) immediately before and nadir SCr 1-3 months after surgery were used to calculate creatinine clearance (CrCl) and glomerular filtration rate (GFR). A cut-off CrCl < 60 mL/min or GFR < 60 mL/min/1.73 m2 was used to determine eligibility for chemotherapy. Results: Median patient age was 70.5 years (IQR 63.77) and median preoperative SCr was 1.05 mg/dL (0.9, 1.3). In total, 80/194 (41%) and 64/194 (33%) patients had inadequate renal function to receive chemotherapy before cystectomy based on CrCl and GFR, respectively. The frequency of inadequate baseline renal function increased significantly with patient age, from 12% of patients < 65 to 54% of patients >65 years of age (P < 0.0001). Surgery did not adversely affect the proportion of patients eligible to receive chemotherapy based on renal function, regardless of age. In fact, after controlling for gender, race, preoperative renal function, hydronephrosis, and choice of diversion, patients <65 years of age were found to have a 14% increase in CrCl (P = .01) and an 11% increase in GFR (P = .04) after cystectomy. Conclusions: Approximately 40% of patients who would be candidates for neoadjuvant chemotherapy could not receive cisplatin because of poor renal function. Surgery did not affect patients' eligibility to receive chemotherapy based on renal function status. Development of effective noncisplatin-based regimens is therefore necessary to optimize survival.

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