Basal forebrain malformation with hyperhidrosis and hypothermia: Variant of Shapiro's syndrome

C. J. Klein, Michael H. Silber, J. R. Halliwill, S. A. Schreiner, G. A. Suarez, P. A. Low

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

A 62-year-old woman presented with episodic sweating and shivering with reduced core temperature. Brain MRI demonstrated a basal forebrain malformation. Physiologic testing included EEG, SPECT, heat challenge, and autonomic testing. Glycopyrrolate aborted spells and raised core temperature. Hypothalamic dysregulation is likely the primary pathophysiology in the setting of other forebrain anomalies. These findings expand the structural abnormalities and treatment options within the temperature dysregulating conditions of Shapiro's syndrome and "diencephalic epilepsy".

Original languageEnglish (US)
Pages (from-to)254-256
Number of pages3
JournalNeurology
Volume56
Issue number2
DOIs
StatePublished - Jan 23 2001

ASJC Scopus subject areas

  • Clinical Neurology

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