Basal forebrain malformation with hyperhidrosis and hypothermia: Variant of Shapiro's syndrome

Christopher Jon Klein, Michael H. Silber, J. R. Halliwill, S. A. Schreiner, G. A. Suarez, Phillip Anson Low

Research output: Contribution to journal › Article

23 Citations (Scopus)

Abstract

A 62-year-old woman presented with episodic sweating and shivering with reduced core temperature. Brain MRI demonstrated a basal forebrain malformation. Physiologic testing included EEG, SPECT, heat challenge, and autonomic testing. Glycopyrrolate aborted spells and raised core temperature. Hypothalamic dysregulation is likely the primary pathophysiology in the setting of other forebrain anomalies. These findings expand the structural abnormalities and treatment options within the temperature dysregulating conditions of Shapiro's syndrome and "diencephalic epilepsy".

Original languageEnglish (US)
Pages (from-to)254-256
Number of pages3
JournalNeurology
Volume56
Issue number2
StatePublished - Jan 23 2001

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Hyperhidrosis
Hypothermia
Temperature
Glycopyrrolate
Shivering
Sweating
Prosencephalon
Single-Photon Emission-Computed Tomography
Electroencephalography
Epilepsy
Hot Temperature
Brain
Shapiro syndrome
Basal Forebrain
Therapeutics

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Klein, C. J., Silber, M. H., Halliwill, J. R., Schreiner, S. A., Suarez, G. A., & Low, P. A. (2001). Basal forebrain malformation with hyperhidrosis and hypothermia: Variant of Shapiro's syndrome. Neurology, 56(2), 254-256.

Basal forebrain malformation with hyperhidrosis and hypothermia : Variant of Shapiro's syndrome. / Klein, Christopher Jon; Silber, Michael H.; Halliwill, J. R.; Schreiner, S. A.; Suarez, G. A.; Low, Phillip Anson.

In: Neurology, Vol. 56, No. 2, 23.01.2001, p. 254-256.

Research output: Contribution to journal › Article

Klein, CJ, Silber, MH, Halliwill, JR, Schreiner, SA, Suarez, GA & Low, PA 2001, 'Basal forebrain malformation with hyperhidrosis and hypothermia: Variant of Shapiro's syndrome', Neurology, vol. 56, no. 2, pp. 254-256.
Klein CJ, Silber MH, Halliwill JR, Schreiner SA, Suarez GA, Low PA. Basal forebrain malformation with hyperhidrosis and hypothermia: Variant of Shapiro's syndrome. Neurology. 2001 Jan 23;56(2):254-256.
Klein, Christopher Jon ; Silber, Michael H. ; Halliwill, J. R. ; Schreiner, S. A. ; Suarez, G. A. ; Low, Phillip Anson. / Basal forebrain malformation with hyperhidrosis and hypothermia : Variant of Shapiro's syndrome. In: Neurology. 2001 ; Vol. 56, No. 2. pp. 254-256.
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