TY - JOUR
T1 - Barriers to drug delivery in interventional oncology
AU - Sheth, Rahul A.
AU - Hesketh, Robin
AU - Kong, David S.
AU - Wicky, Stephan
AU - Oklu, Rahmi
N1 - Funding Information:
This work was sponsored by the Assistant Secretary of Defense for Research and Engineering under Air Force Contract FA8721-05-C-0002. Opinions, interpretations, recommendations, and conclusions are those of the authors and are not necessarily endorsed by the United States Government. None of the authors have identified a conflict of interest.
Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2013/8
Y1 - 2013/8
N2 - Although much attention has been paid to mechanisms of anticancer drug resistance that focus on intracellular processes that protect tumor cells, it has recently become increasingly evident that the unique features of the tumor microenvironment profoundly impact the efficacy of cancer therapies. The properties of this extracellular milieu, including increased interstitial pressure, decreased pH, hypoxia, and abnormal vascularity, result in limited drug efficacy; this finding is true not only for systemic chemotherapy but also for catheter-based therapies, including chemoembolization and radioembolization. The present review summarizes the barriers to drug delivery imposed by the tumor microenvironment and provides methods to overcome these hurdles.
AB - Although much attention has been paid to mechanisms of anticancer drug resistance that focus on intracellular processes that protect tumor cells, it has recently become increasingly evident that the unique features of the tumor microenvironment profoundly impact the efficacy of cancer therapies. The properties of this extracellular milieu, including increased interstitial pressure, decreased pH, hypoxia, and abnormal vascularity, result in limited drug efficacy; this finding is true not only for systemic chemotherapy but also for catheter-based therapies, including chemoembolization and radioembolization. The present review summarizes the barriers to drug delivery imposed by the tumor microenvironment and provides methods to overcome these hurdles.
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U2 - 10.1016/j.jvir.2013.03.034
DO - 10.1016/j.jvir.2013.03.034
M3 - Review article
C2 - 23735316
AN - SCOPUS:84880712433
SN - 1051-0443
VL - 24
SP - 1201
EP - 1207
JO - Journal of Vascular and Interventional Radiology
JF - Journal of Vascular and Interventional Radiology
IS - 8
ER -