Barriers and strategies for the clinical translation of advanced orthopaedic tissue engineering protocols

H. Madry, M. Alini, M. J. Stoddart, Christopher H Evans, T. Miclau, Sandra Steiner

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Research in orthopaedic tissue engineering has intensified over the last decade and new protocols continue to emerge. The clinical translation of these new applications, however, remains associated with a number of obstacles. This report highlights the major issues that impede the clinical translation of advanced tissue engineering concepts, discusses strategies to overcome these barriers, and examines the need to increase incentives for translational strategies. The statements are based on presentations and discussions held at the AO Foundation-sponsored symposium "Where Science meets Clinics 2013" held at the Congress Center in Davos, Switzerland, in September, 2013. The event organisers convened a diverse group of over one hundred stakeholders involved in clinical translation of orthopaedic tissue engineering, including scientists, clinicians, healthcare industry professionals and regulatory agency representatives. A major point that emerged from the discussions was that there continues to be a critical need for early trans-disciplinary communication and collaboration in the development and execution of research approaches. Equally importantly was the need to address the shortage of sustained funding programs for multidisciplinary teams conducting translational research. Such detailed discussions between experts contribute towards the development of a roadmap to more successfully advance the clinical translation of novel tissue engineering concepts and ultimately improve patient care in orthopaedic and trauma surgery.

Original languageEnglish (US)
Pages (from-to)17-21
Number of pages5
JournalEuropean Cells and Materials
Volume27
Issue numberSUPPL
StatePublished - May 6 2014
Externally publishedYes

Fingerprint

Orthopedics
Tissue Engineering
Tissue engineering
Health Care Sector
Translational Medical Research
Switzerland
Research
Surgery
Motivation
Patient Care
Communication
Wounds and Injuries
Industry

Keywords

  • Articular cartilage repair
  • Clinical translation
  • Regenerative medicine
  • Tissue engineering
  • Translational barriers

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Bioengineering
  • Biomedical Engineering
  • Biomaterials

Cite this

Barriers and strategies for the clinical translation of advanced orthopaedic tissue engineering protocols. / Madry, H.; Alini, M.; Stoddart, M. J.; Evans, Christopher H; Miclau, T.; Steiner, Sandra.

In: European Cells and Materials, Vol. 27, No. SUPPL, 06.05.2014, p. 17-21.

Research output: Contribution to journalArticle

Madry, H, Alini, M, Stoddart, MJ, Evans, CH, Miclau, T & Steiner, S 2014, 'Barriers and strategies for the clinical translation of advanced orthopaedic tissue engineering protocols', European Cells and Materials, vol. 27, no. SUPPL, pp. 17-21.
Madry, H. ; Alini, M. ; Stoddart, M. J. ; Evans, Christopher H ; Miclau, T. ; Steiner, Sandra. / Barriers and strategies for the clinical translation of advanced orthopaedic tissue engineering protocols. In: European Cells and Materials. 2014 ; Vol. 27, No. SUPPL. pp. 17-21.
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