Ballooned neurons in select neurodegenerative diseases contain phosphorylated neurofilament epitopes

Dennis W Dickson, S. H. Yen, K. I. Suzuki, P. Davies, J. H. Garcia, A. Hirano

Research output: Contribution to journalArticle

137 Citations (Scopus)

Abstract

Ballooned neurons are histological features of several neurodegenerative diseases of the central nervous system. We describe the immunocytochemical staining of ballooned neurons in Pick's disease, unclassified dementia, corticonigral degeneration, pigment-spheroid degeneration and Alzheimer's disease. In all of these conditions the ballooned neurons contain phosphorylated epitopes recognized by monoclonal antibodies to neurofilaments, but not epitopes unique to Alzheimer neurofibrillary tangles and Pick bodies. The morphological features and immunohistochemical properties of ballooned neurons in these disorders bear resemblance to swollen neurons produced by neurotoxins that impair axoplasmic transport of neurofilaments. This finding, by analogy, suggests that impaired axoplasmic transport of neurofilaments may be a common mechanism in various dementing neurodegenerative diseases.

Original languageEnglish (US)
Pages (from-to)216-223
Number of pages8
JournalActa Neuropathologica
Volume71
Issue number3-4
DOIs
StatePublished - Sep 1986
Externally publishedYes

Fingerprint

Intermediate Filaments
Neurodegenerative Diseases
Epitopes
Neurons
Axonal Transport
Pick Disease of the Brain
Neurofibrillary Tangles
Neurotoxins
Dementia
Alzheimer Disease
Central Nervous System
Monoclonal Antibodies
Staining and Labeling

Keywords

  • Dementia
  • Immunohistochemistry
  • Neurofilament
  • Phosphorylation

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pathology and Forensic Medicine
  • Clinical Neurology

Cite this

Ballooned neurons in select neurodegenerative diseases contain phosphorylated neurofilament epitopes. / Dickson, Dennis W; Yen, S. H.; Suzuki, K. I.; Davies, P.; Garcia, J. H.; Hirano, A.

In: Acta Neuropathologica, Vol. 71, No. 3-4, 09.1986, p. 216-223.

Research output: Contribution to journalArticle

Dickson, Dennis W ; Yen, S. H. ; Suzuki, K. I. ; Davies, P. ; Garcia, J. H. ; Hirano, A. / Ballooned neurons in select neurodegenerative diseases contain phosphorylated neurofilament epitopes. In: Acta Neuropathologica. 1986 ; Vol. 71, No. 3-4. pp. 216-223.
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