TY - JOUR
T1 - Balanced efficacy, safety, and tolerability recommendations for the clinical management of bipolar disorder
AU - Malhi, Gin S.
AU - Bargh, Danielle M.
AU - Mcintyre, Roger
AU - Gitlin, Michael
AU - Frye, Mark A.
AU - Bauer, Michael
AU - Berk, Michael
PY - 2012/5
Y1 - 2012/5
N2 - Objective: To provide practical and clinically meaningful treatment recommendations that amalgamate clinical experience and research findings for each phase of bipolar disorder. Methods: A comprehensive search of the literature was undertaken using electronic database search engines (Medline, PubMed, Cochrane reviews) using key words (e.g., bipolar depression, mania, treatment). All relevant randomised controlled trials were examined, along with review papers, meta-analyses, and book chapters known to the authors. In addition, the recommendations from accompanying papers in this supplement have been distilled and captured in the form of summary boxes. The findings, in conjunction with the clinical experience of international researchers and clinicians who are practiced in treating mood disorders, formed the basis of the treatment recommendations within this paper. Results: Balancing clinical experience with evidence informed and lead to the development of practical clinical recommendations that emphasise the importance of safety and tolerability alongside efficacy in the clinical management of bipolar disorder. Conclusions: The current paper summarises the treatment recommendations relating to each phase of bipolar disorder while providing additional, evidence-based, practical insights. Medication-related side effects and monitoring strategies highlight the importance of safety and tolerability considerations, which, along with efficacy information, should be given equal merit.
AB - Objective: To provide practical and clinically meaningful treatment recommendations that amalgamate clinical experience and research findings for each phase of bipolar disorder. Methods: A comprehensive search of the literature was undertaken using electronic database search engines (Medline, PubMed, Cochrane reviews) using key words (e.g., bipolar depression, mania, treatment). All relevant randomised controlled trials were examined, along with review papers, meta-analyses, and book chapters known to the authors. In addition, the recommendations from accompanying papers in this supplement have been distilled and captured in the form of summary boxes. The findings, in conjunction with the clinical experience of international researchers and clinicians who are practiced in treating mood disorders, formed the basis of the treatment recommendations within this paper. Results: Balancing clinical experience with evidence informed and lead to the development of practical clinical recommendations that emphasise the importance of safety and tolerability alongside efficacy in the clinical management of bipolar disorder. Conclusions: The current paper summarises the treatment recommendations relating to each phase of bipolar disorder while providing additional, evidence-based, practical insights. Medication-related side effects and monitoring strategies highlight the importance of safety and tolerability considerations, which, along with efficacy information, should be given equal merit.
KW - Acute treatment
KW - Bipolar disorder
KW - Evidence-based review
KW - Guidelines
KW - Maintenance treatment
KW - Treatment
UR - http://www.scopus.com/inward/record.url?scp=84859829264&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84859829264&partnerID=8YFLogxK
U2 - 10.1111/j.1399-5618.2012.00989.x
DO - 10.1111/j.1399-5618.2012.00989.x
M3 - Review article
C2 - 22510033
AN - SCOPUS:84859829264
SN - 1398-5647
VL - 14
SP - 1
EP - 21
JO - Bipolar disorders
JF - Bipolar disorders
IS - SUPPL.2
ER -