BAL findings in idiopathic nonspecific interstitial pneumonia and usual interstitial pneumonia

S. Veeraraghavan, P. I. Latsi, A. U. Wells, P. Pantelidis, P. Pantelidis, A. G. Nicholson, T. V. Colby, P. L. Haslam, E. A. Renzoni, R. M. du Bois

Research output: Contribution to journalArticle

114 Citations (Scopus)

Abstract

Idiopathic pulmonary fibrosis (IPF), which has the histological pattern of usual interstitial pneumonia (UIP), is a progressive interstitial lung disease with a poor prognosis. Idiopathic interstitial pneumonias with a histological pattern of nonspecific interstitial pneumonia (NSIP) have a better prognosis than UIP, and may present with a clinical picture identical to IPF. The authors hypothesised that bronchoalveolar lavage (BAL) findings may distinguish between UIP and NSIP, and have prognostic value within disease subgroups. BAL findings were studied retrospectively in 54 patients with histologically proven (surgical biopsy) idiopathic UIP (n=35) or fibrotic NSIP (n=19), all presenting clinically as IPF. These findings were also compared with the BAL profile of patients with other categories of idiopathic interstitial pneumonias. BAL total and differential cell counts did not differ between the two groups. Survival was better in NSIP. In neither group were BAL findings predictive of survival or changes in lung function at 1 yr, even after adjustment for disease severity, smoking and treatment. BAL differential counts in fibrotic NSIP differed from respiratory bronchiolitis-associated interstitial lung disease, but not from desquamative interstitial pneumonia or cellular NSIP. The authors conclude that bronchoalveolar lavage findings do not discriminate between usual interstitial pneumonia and nonspecific interstitial pneumonia in patients presenting with clinical features of idiopathic pulmonary fibrosis, and have no prognostic value, once the distinction between the two has been made histologically.

Original languageEnglish (US)
Pages (from-to)239-244
Number of pages6
JournalEuropean Respiratory Journal
Volume22
Issue number2
DOIs
StatePublished - Aug 1 2003

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Idiopathic Interstitial Pneumonias
Idiopathic Pulmonary Fibrosis
Interstitial Lung Diseases
Bronchoalveolar Lavage
Bronchiolitis
Survival
Cell Count
Smoking

Keywords

  • Bronchoalveolar lavage
  • Interstitial lung disease
  • Pulmonary fibrosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Veeraraghavan, S., Latsi, P. I., Wells, A. U., Pantelidis, P., Pantelidis, P., Nicholson, A. G., ... du Bois, R. M. (2003). BAL findings in idiopathic nonspecific interstitial pneumonia and usual interstitial pneumonia. European Respiratory Journal, 22(2), 239-244. https://doi.org/10.1183/09031936.03.00105202

BAL findings in idiopathic nonspecific interstitial pneumonia and usual interstitial pneumonia. / Veeraraghavan, S.; Latsi, P. I.; Wells, A. U.; Pantelidis, P.; Pantelidis, P.; Nicholson, A. G.; Colby, T. V.; Haslam, P. L.; Renzoni, E. A.; du Bois, R. M.

In: European Respiratory Journal, Vol. 22, No. 2, 01.08.2003, p. 239-244.

Research output: Contribution to journalArticle

Veeraraghavan, S, Latsi, PI, Wells, AU, Pantelidis, P, Pantelidis, P, Nicholson, AG, Colby, TV, Haslam, PL, Renzoni, EA & du Bois, RM 2003, 'BAL findings in idiopathic nonspecific interstitial pneumonia and usual interstitial pneumonia', European Respiratory Journal, vol. 22, no. 2, pp. 239-244. https://doi.org/10.1183/09031936.03.00105202
Veeraraghavan S, Latsi PI, Wells AU, Pantelidis P, Pantelidis P, Nicholson AG et al. BAL findings in idiopathic nonspecific interstitial pneumonia and usual interstitial pneumonia. European Respiratory Journal. 2003 Aug 1;22(2):239-244. https://doi.org/10.1183/09031936.03.00105202
Veeraraghavan, S. ; Latsi, P. I. ; Wells, A. U. ; Pantelidis, P. ; Pantelidis, P. ; Nicholson, A. G. ; Colby, T. V. ; Haslam, P. L. ; Renzoni, E. A. ; du Bois, R. M. / BAL findings in idiopathic nonspecific interstitial pneumonia and usual interstitial pneumonia. In: European Respiratory Journal. 2003 ; Vol. 22, No. 2. pp. 239-244.
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