Bacterial lipase and high-fat diets in canine exocrine pancreatic insufficiency: A new therapy of steatorrhea?

A. Suzuki, A. Mizumoto, M. G. Sarr, E. P. DiMagno

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Background and Aims: Nutrients and properties of lipases affect survival of lipolytic activity during aboral gastrointestinal transit. Whether different doses and formulations of bacterial lipase and diets affect steatorrhea was tested in pancreatic-insufficient dogs. Methods: A dose of 0- 600,000 IU of powdered and 135,000 and 300,000 IU of liquid bacterial lipase was given with a standard meal to 5 dogs with ligated pancreatic ducts. In 4 dogs, 0 or 300,000 IU (normal 6-hour postprandial amount) of powder bacterial lipase was also given with five meals containing 850 kcal with different nutrient caloric densities (mixture design). Coefficients of fat absorption during 72-hour fecal balance studies were used to assess treatments. Results: With the standard meal, powder bacterial lipase reduced steatorrhea in a dose-dependent manner (P = 0.03), and 135,000 and 300,000 IU of the liquid form decreased steatorrhea more than powder bacterial lipase (P = 0.017 and 0.057, respectively). Coefficients of fat absorption with 300,000 IU of powder bacterial lipase correlated (r2 = 0.79; P < 0.001) with increasing proportions of fat calories in diets. Conclusions: Liquid bacterial lipase decreases steatorrhea more than powder, and 300,000 IU of powder bacterial lipase ingested with high-fat meals corrects canine pancreatic steatorrhea. The combination of adequate mixing of small amounts (milligrams) of bacterial lipase and high-fat meals abolishes canine steatorrhea and may abolish human pancreatic steatorrhea.

Original languageEnglish (US)
Pages (from-to)2048-2055
Number of pages8
JournalGastroenterology
Volume112
Issue number6
DOIs
StatePublished - 1997

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Steatorrhea
Exocrine Pancreatic Insufficiency
High Fat Diet
Lipase
Canidae
Powders
Meals
Fats
Therapeutics
Dogs
Gastrointestinal Transit
Diet
Food
Pancreatic Ducts

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Bacterial lipase and high-fat diets in canine exocrine pancreatic insufficiency : A new therapy of steatorrhea? / Suzuki, A.; Mizumoto, A.; Sarr, M. G.; DiMagno, E. P.

In: Gastroenterology, Vol. 112, No. 6, 1997, p. 2048-2055.

Research output: Contribution to journalArticle

Suzuki, A. ; Mizumoto, A. ; Sarr, M. G. ; DiMagno, E. P. / Bacterial lipase and high-fat diets in canine exocrine pancreatic insufficiency : A new therapy of steatorrhea?. In: Gastroenterology. 1997 ; Vol. 112, No. 6. pp. 2048-2055.
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