B7-H3 enhances tumor immunity in vivo by costimulating rapid clonal expansion of antigen-specific CD8+ cytolytic T cells

Liqun Luo, Andrei I. Chapoval, Dallas B. Flies, Gefeng Zhu, Fumiya Hirano, Shengdian Wang, Julie S. Lau, Haidong Dong, Koji Tamada, Andrew S. Flies, Yang Liu, Lieping Chen

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129 Scopus citations

Abstract

B7-H3 is a B7 family molecule with T cell costimulatory function in vitro. The in vivo role of B7-H3 in the stimulation of tumor immunity is unclear. We report here that expression of B7-H3 by transfection of the mouse P815 tumor line enhances its immunogenicity, leading to the regression of tumors and amplification of a tumor-specific CD8+ CTL response in syngeneic mice. Tumor cells engineered to express B7-H3 elicit a rapid clonal expansion of P1A tumor Ag-specific CD8+ CTL in lymphoid organs in vivo and acquire the ability to directly stimulate T cell growth, division, and development of cytolytic activity in vitro. Our results thus establish a role for B7-H3 in the costimulation of T cell immune responses in vivo.

Original languageEnglish (US)
Pages (from-to)5445-5450
Number of pages6
JournalJournal of Immunology
Volume173
Issue number9
DOIs
StatePublished - Nov 1 2004

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Luo, L., Chapoval, A. I., Flies, D. B., Zhu, G., Hirano, F., Wang, S., Lau, J. S., Dong, H., Tamada, K., Flies, A. S., Liu, Y., & Chen, L. (2004). B7-H3 enhances tumor immunity in vivo by costimulating rapid clonal expansion of antigen-specific CD8+ cytolytic T cells. Journal of Immunology, 173(9), 5445-5450. https://doi.org/10.4049/jimmunol.173.9.5445