B7-H1 (PD-L1, CD274) suppresses host immunity in T-cell lymphoproliferative disorders

Ryan A. Wilcox, Andrew L. Feldman, David A. Wada, Zhi Zhang Yang, Nneka I. Comfere, Haidong Dong, Eugene D. Kwon, Anne J. Novak, Svetomir N. Markovic, Mark R. Pittelkow, Thomas E. Witzig, Stephen M. Ansell

Research output: Contribution to journalArticle

144 Scopus citations

Abstract

Stromal elements present within the tumor microenvironment may suppress host immunity and promote the growth of malignant lymphocytes in B cell-derived non-Hodgkin lymphoma (NHL). In contrast, little is known about the microenvironment's role in T cell-derived NHL. B7-H1 (PD-L1, CD274), a member of the B7 family of costimulatory/coinhibitory ligands expressed by both malignant cells and stromal cells within the tumor microenvironment, has emerged as an important immune modulator capable of suppressing host immunity. Therefore, B7-H1 expression and function were analyzed in cutaneous and peripheral T-cell NHL. B7-H1 was expressed by tumor cells, monocytes, and monocyte-derived cells within the tumor microenvironment in T-cell NHL and was found to inhibit T-cell proliferation and promote the induction of FoxP3+ regulatory T cells. Collectively, the data presented provide the first evidence implicating B7-H1 in the suppression of host immunity in T-cell lymphoproliferative disorders and suggest that the targeting of B7-H1 may represent a novel therapeutic approach.

Original languageEnglish (US)
Pages (from-to)2149-2158
Number of pages10
JournalBlood
Volume114
Issue number10
DOIs
StatePublished - 2009

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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