B7-H1 (PD-L1, CD274) suppresses host immunity in T-cell lymphoproliferative disorders

Ryan A. Wilcox, Andrew L Feldman, David A. Wada, Zhi Zhang Yang, Nneka I. Comfere, Haidong M Dong, Eugene D Kwon, Anne J Novak, Svetomir Nenad Markovic, Mark R. Pittelkow, Thomas Elmer Witzig, Stephen Maxted Ansell

Research output: Contribution to journalArticle

124 Citations (Scopus)

Abstract

Stromal elements present within the tumor microenvironment may suppress host immunity and promote the growth of malignant lymphocytes in B cell-derived non-Hodgkin lymphoma (NHL). In contrast, little is known about the microenvironment's role in T cell-derived NHL. B7-H1 (PD-L1, CD274), a member of the B7 family of costimulatory/coinhibitory ligands expressed by both malignant cells and stromal cells within the tumor microenvironment, has emerged as an important immune modulator capable of suppressing host immunity. Therefore, B7-H1 expression and function were analyzed in cutaneous and peripheral T-cell NHL. B7-H1 was expressed by tumor cells, monocytes, and monocyte-derived cells within the tumor microenvironment in T-cell NHL and was found to inhibit T-cell proliferation and promote the induction of FoxP3+ regulatory T cells. Collectively, the data presented provide the first evidence implicating B7-H1 in the suppression of host immunity in T-cell lymphoproliferative disorders and suggest that the targeting of B7-H1 may represent a novel therapeutic approach.

Original languageEnglish (US)
Pages (from-to)2149-2158
Number of pages10
JournalBlood
Volume114
Issue number10
DOIs
StatePublished - 2009

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T-cells
Lymphoproliferative Disorders
Non-Hodgkin's Lymphoma
Tumor Microenvironment
Immunity
T-Lymphocytes
Tumors
Monocytes
Peripheral T-Cell Lymphoma
T-Cell Lymphoma
Regulatory T-Lymphocytes
Stromal Cells
Cells
B-Lymphocytes
Lymphocytes
Cell Proliferation
Cell proliferation
Ligands
Skin
Modulators

ASJC Scopus subject areas

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology

Cite this

B7-H1 (PD-L1, CD274) suppresses host immunity in T-cell lymphoproliferative disorders. / Wilcox, Ryan A.; Feldman, Andrew L; Wada, David A.; Yang, Zhi Zhang; Comfere, Nneka I.; Dong, Haidong M; Kwon, Eugene D; Novak, Anne J; Markovic, Svetomir Nenad; Pittelkow, Mark R.; Witzig, Thomas Elmer; Ansell, Stephen Maxted.

In: Blood, Vol. 114, No. 10, 2009, p. 2149-2158.

Research output: Contribution to journalArticle

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abstract = "Stromal elements present within the tumor microenvironment may suppress host immunity and promote the growth of malignant lymphocytes in B cell-derived non-Hodgkin lymphoma (NHL). In contrast, little is known about the microenvironment's role in T cell-derived NHL. B7-H1 (PD-L1, CD274), a member of the B7 family of costimulatory/coinhibitory ligands expressed by both malignant cells and stromal cells within the tumor microenvironment, has emerged as an important immune modulator capable of suppressing host immunity. Therefore, B7-H1 expression and function were analyzed in cutaneous and peripheral T-cell NHL. B7-H1 was expressed by tumor cells, monocytes, and monocyte-derived cells within the tumor microenvironment in T-cell NHL and was found to inhibit T-cell proliferation and promote the induction of FoxP3+ regulatory T cells. Collectively, the data presented provide the first evidence implicating B7-H1 in the suppression of host immunity in T-cell lymphoproliferative disorders and suggest that the targeting of B7-H1 may represent a novel therapeutic approach.",
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AU - Ansell, Stephen Maxted

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