B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression

Daria Trabattoni, Marina Saresella, Mara Biasin, Adriano Boasso, Luca Piacentini, Pasquale Ferrante, Haidong M Dong, Renato Maserati, Gene M. Shearer, Lieping Chen, Mario Clerici

Research output: Contribution to journalArticle

137 Citations (Scopus)

Abstract

The ligation of programmed death-ligand I (B7-H1) to T cells results in the preferential production of interleukin 10 (IL-10). We investigated if B7-H1 would be up-regulated in HIV infection, a disease characterized by increased IL-10 production, by measuring B7-H1, B7-1 (CD80), and B7-2 (CD86) expression and mRNA in 36 HIV-infected patients and in 22 healthy controls (HCs). Results showed that (1) B7-H1 expression and mRNA are augmented in cells of HIV patients; (2) increased IL-10 production in these patients is largely induced by B7-H1-expressing CD14+ cells; (3) an inverse correlation is detected between B7-H1 expression and CD4 counts, whereas the up-regulation of B7-H1 is directly associated with HIV plasma viremia; (4) antiviral therapy results in the parallel down modulation of IL-10 production and B7-H1 expression/ synthesis; and (5) B7-H1/CD80 and B7-H1/ CD86 mRNA ratios are increased in peripheral blood mononuclear cells (PBMCs) of HIV patients compared with HCs. B7-H1 synthesis and expression are up-regulated in HIV infection, and the degree of dysregulation correlates with the severity of disease. Aberrant antigen presentation by antigen-presenting cells (APCs) that exhibit increased B7-H1 expression and IL-10 production in HIV infection could be responsible for T-lymphocyte unresponsiveness and loss of protective immunity. B7-H1 is a surrogate marker potentially involved in AIDS disease progression.

Original languageEnglish (US)
Pages (from-to)2514-2520
Number of pages7
JournalBlood
Volume101
Issue number7
DOIs
StatePublished - Apr 1 2003
Externally publishedYes

Fingerprint

Interleukin-10
HIV Infections
Disease Progression
Biomarkers
HIV
T-cells
Messenger RNA
T-Lymphocytes
Viremia
Antigen Presentation
Antigen-Presenting Cells
CD4 Lymphocyte Count
Antiviral Agents
Ligation
Immunity
Blood Cells
Acquired Immunodeficiency Syndrome
Blood
Up-Regulation
Modulation

ASJC Scopus subject areas

  • Hematology

Cite this

Trabattoni, D., Saresella, M., Biasin, M., Boasso, A., Piacentini, L., Ferrante, P., ... Clerici, M. (2003). B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression. Blood, 101(7), 2514-2520. https://doi.org/10.1182/blood-2002-10-3065

B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression. / Trabattoni, Daria; Saresella, Marina; Biasin, Mara; Boasso, Adriano; Piacentini, Luca; Ferrante, Pasquale; Dong, Haidong M; Maserati, Renato; Shearer, Gene M.; Chen, Lieping; Clerici, Mario.

In: Blood, Vol. 101, No. 7, 01.04.2003, p. 2514-2520.

Research output: Contribution to journalArticle

Trabattoni, D, Saresella, M, Biasin, M, Boasso, A, Piacentini, L, Ferrante, P, Dong, HM, Maserati, R, Shearer, GM, Chen, L & Clerici, M 2003, 'B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression', Blood, vol. 101, no. 7, pp. 2514-2520. https://doi.org/10.1182/blood-2002-10-3065
Trabattoni D, Saresella M, Biasin M, Boasso A, Piacentini L, Ferrante P et al. B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression. Blood. 2003 Apr 1;101(7):2514-2520. https://doi.org/10.1182/blood-2002-10-3065
Trabattoni, Daria ; Saresella, Marina ; Biasin, Mara ; Boasso, Adriano ; Piacentini, Luca ; Ferrante, Pasquale ; Dong, Haidong M ; Maserati, Renato ; Shearer, Gene M. ; Chen, Lieping ; Clerici, Mario. / B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression. In: Blood. 2003 ; Vol. 101, No. 7. pp. 2514-2520.
@article{51f8d98f2df5440cb2a447e4e7903526,
title = "B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression",
abstract = "The ligation of programmed death-ligand I (B7-H1) to T cells results in the preferential production of interleukin 10 (IL-10). We investigated if B7-H1 would be up-regulated in HIV infection, a disease characterized by increased IL-10 production, by measuring B7-H1, B7-1 (CD80), and B7-2 (CD86) expression and mRNA in 36 HIV-infected patients and in 22 healthy controls (HCs). Results showed that (1) B7-H1 expression and mRNA are augmented in cells of HIV patients; (2) increased IL-10 production in these patients is largely induced by B7-H1-expressing CD14+ cells; (3) an inverse correlation is detected between B7-H1 expression and CD4 counts, whereas the up-regulation of B7-H1 is directly associated with HIV plasma viremia; (4) antiviral therapy results in the parallel down modulation of IL-10 production and B7-H1 expression/ synthesis; and (5) B7-H1/CD80 and B7-H1/ CD86 mRNA ratios are increased in peripheral blood mononuclear cells (PBMCs) of HIV patients compared with HCs. B7-H1 synthesis and expression are up-regulated in HIV infection, and the degree of dysregulation correlates with the severity of disease. Aberrant antigen presentation by antigen-presenting cells (APCs) that exhibit increased B7-H1 expression and IL-10 production in HIV infection could be responsible for T-lymphocyte unresponsiveness and loss of protective immunity. B7-H1 is a surrogate marker potentially involved in AIDS disease progression.",
author = "Daria Trabattoni and Marina Saresella and Mara Biasin and Adriano Boasso and Luca Piacentini and Pasquale Ferrante and Dong, {Haidong M} and Renato Maserati and Shearer, {Gene M.} and Lieping Chen and Mario Clerici",
year = "2003",
month = "4",
day = "1",
doi = "10.1182/blood-2002-10-3065",
language = "English (US)",
volume = "101",
pages = "2514--2520",
journal = "Blood",
issn = "0006-4971",
publisher = "American Society of Hematology",
number = "7",

}

TY - JOUR

T1 - B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression

AU - Trabattoni, Daria

AU - Saresella, Marina

AU - Biasin, Mara

AU - Boasso, Adriano

AU - Piacentini, Luca

AU - Ferrante, Pasquale

AU - Dong, Haidong M

AU - Maserati, Renato

AU - Shearer, Gene M.

AU - Chen, Lieping

AU - Clerici, Mario

PY - 2003/4/1

Y1 - 2003/4/1

N2 - The ligation of programmed death-ligand I (B7-H1) to T cells results in the preferential production of interleukin 10 (IL-10). We investigated if B7-H1 would be up-regulated in HIV infection, a disease characterized by increased IL-10 production, by measuring B7-H1, B7-1 (CD80), and B7-2 (CD86) expression and mRNA in 36 HIV-infected patients and in 22 healthy controls (HCs). Results showed that (1) B7-H1 expression and mRNA are augmented in cells of HIV patients; (2) increased IL-10 production in these patients is largely induced by B7-H1-expressing CD14+ cells; (3) an inverse correlation is detected between B7-H1 expression and CD4 counts, whereas the up-regulation of B7-H1 is directly associated with HIV plasma viremia; (4) antiviral therapy results in the parallel down modulation of IL-10 production and B7-H1 expression/ synthesis; and (5) B7-H1/CD80 and B7-H1/ CD86 mRNA ratios are increased in peripheral blood mononuclear cells (PBMCs) of HIV patients compared with HCs. B7-H1 synthesis and expression are up-regulated in HIV infection, and the degree of dysregulation correlates with the severity of disease. Aberrant antigen presentation by antigen-presenting cells (APCs) that exhibit increased B7-H1 expression and IL-10 production in HIV infection could be responsible for T-lymphocyte unresponsiveness and loss of protective immunity. B7-H1 is a surrogate marker potentially involved in AIDS disease progression.

AB - The ligation of programmed death-ligand I (B7-H1) to T cells results in the preferential production of interleukin 10 (IL-10). We investigated if B7-H1 would be up-regulated in HIV infection, a disease characterized by increased IL-10 production, by measuring B7-H1, B7-1 (CD80), and B7-2 (CD86) expression and mRNA in 36 HIV-infected patients and in 22 healthy controls (HCs). Results showed that (1) B7-H1 expression and mRNA are augmented in cells of HIV patients; (2) increased IL-10 production in these patients is largely induced by B7-H1-expressing CD14+ cells; (3) an inverse correlation is detected between B7-H1 expression and CD4 counts, whereas the up-regulation of B7-H1 is directly associated with HIV plasma viremia; (4) antiviral therapy results in the parallel down modulation of IL-10 production and B7-H1 expression/ synthesis; and (5) B7-H1/CD80 and B7-H1/ CD86 mRNA ratios are increased in peripheral blood mononuclear cells (PBMCs) of HIV patients compared with HCs. B7-H1 synthesis and expression are up-regulated in HIV infection, and the degree of dysregulation correlates with the severity of disease. Aberrant antigen presentation by antigen-presenting cells (APCs) that exhibit increased B7-H1 expression and IL-10 production in HIV infection could be responsible for T-lymphocyte unresponsiveness and loss of protective immunity. B7-H1 is a surrogate marker potentially involved in AIDS disease progression.

UR - http://www.scopus.com/inward/record.url?scp=0038784354&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038784354&partnerID=8YFLogxK

U2 - 10.1182/blood-2002-10-3065

DO - 10.1182/blood-2002-10-3065

M3 - Article

C2 - 12468426

AN - SCOPUS:0038784354

VL - 101

SP - 2514

EP - 2520

JO - Blood

JF - Blood

SN - 0006-4971

IS - 7

ER -